| UniProt ID | XYLT1_HUMAN | |
|---|---|---|
| UniProt AC | Q86Y38 | |
| Protein Name | Xylosyltransferase 1 | |
| Gene Name | XYLT1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 959 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type II membrane protein. Golgi apparatus membrane Single-pass type II membrane protein. Secreted . Some fraction is also found in the extracellular space together with chondroitin sulfate proteoglycans, |
|
| Protein Description | Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes.. | |
| Protein Sequence | MVAAPCARRLARRSHSALLAALTVLLLQTLVVWNFSSLDSGAGERRGGAAVGGGEQPPPAPAPRRERRDLPAEPAAARGGGGGGGGGGGGRGPQARARGGGPGEPRGQQPASRGALPARALDPHPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSNFAPRTQKQKHQPELAKKPPSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAANSSHGKDVSRPPHARKTGGSSPETKYDQPPKCDISGKEAISALSRAKSKHCRQEIGETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDEDSVEYMPANPVRIAFVLVVHGRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGASLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFSTDDLVTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCGCSPNDFKPQDFHRFQQTARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWENVYDEPDGIHSLSDVTLTLYHSFARLGLRRAETSLHTDGENSCRYYPMGHPASVHLYFLADRFQGFLIKHHATNLAVSKLETLETWVMPKKVFKIASPPSDFGRLQFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAEFTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNRQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPINPAQVEQARRNAASTGTALEGWLDSLVGGMWTAMDICATGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 126 | O-linked_Glycosylation | RALDPHPSPLITLET HHCCCCCCCCEEEEE | 29.33 | OGP | |
| 133 | O-linked_Glycosylation | SPLITLETQDGYFSH CCCEEEEECCCCCCC | 34.76 | OGP | |
| 143 | Acetylation | GYFSHRPKEKVRTDS CCCCCCCHHHCCCCC | 70.85 | 11567263 | |
| 155 | O-linked_Glycosylation | TDSNNENSVPKDFEN CCCCCCCCCCCCCCC | 33.35 | OGP | |
| 207 | O-linked_Glycosylation | QEKGKGHTFPGKGPG HHCCCCCCCCCCCCC | 39.95 | OGP | |
| 226 | N-linked_Glycosylation | PGDRAAANSSHGKDV CCCHHCCCCCCCCCC | 39.04 | UniProtKB CARBOHYD | |
| 227 | Phosphorylation | GDRAAANSSHGKDVS CCHHCCCCCCCCCCC | 20.98 | - | |
| 228 | Phosphorylation | DRAAANSSHGKDVSR CHHCCCCCCCCCCCC | 35.75 | - | |
| 241 | Acetylation | SRPPHARKTGGSSPE CCCCCCCCCCCCCCC | 52.91 | 19413330 | |
| 245 | Phosphorylation | HARKTGGSSPETKYD CCCCCCCCCCCCCCC | 44.03 | 27251275 | |
| 246 | Phosphorylation | ARKTGGSSPETKYDQ CCCCCCCCCCCCCCC | 29.99 | 27251275 | |
| 260 | Phosphorylation | QPPKCDISGKEAISA CCCCCCCCHHHHHHH | 30.48 | 22199227 | |
| 317 | Phosphorylation | NVQWDEDSVEYMPAN CCCCCCCCCCEECCC | 18.14 | 27251275 | |
| 378 | Phosphorylation | VLQVSRQYSNVRVTP HHHHHHHHCCCCCCC | 10.91 | - | |
| 379 | Phosphorylation | LQVSRQYSNVRVTPW HHHHHHHCCCCCCCC | 22.10 | - | |
| 421 | N-linked_Glycosylation | WPWDFFINLSAADYP CCCCCEEEHHHCCCC | 23.84 | UniProtKB CARBOHYD | |
| 449 | Ubiquitination | YRDMNFLKSHGRDNA HHCHHHHHHCCCCCH | 35.95 | - | |
| 590 | Phosphorylation | DFHRFQQTARPTFFA HHHHHHHCCCCCHHH | 17.53 | - | |
| 665 | Phosphorylation | LGLRRAETSLHTDGE HCCCCCEEEEECCCC | 35.29 | - | |
| 666 | Phosphorylation | GLRRAETSLHTDGEN CCCCCEEEEECCCCC | 15.06 | - | |
| 669 | Phosphorylation | RAETSLHTDGENSCR CCEEEEECCCCCCCC | 51.50 | - | |
| 674 | Phosphorylation | LHTDGENSCRYYPMG EECCCCCCCCEECCC | 8.82 | - | |
| 777 | N-linked_Glycosylation | QKWGKGPNVTVTVIW HHCCCCCCEEEEEEE | 51.24 | 29681470 | |
| 871 | O-linked_Glycosylation | RNAYMEQSFQSLNPV CHHHHHHHHHHCCCH | 16.37 | OGP | |
| 874 | O-linked_Glycosylation | YMEQSFQSLNPVLSL HHHHHHHHCCCHHCC | 28.27 | OGP | |
| 880 | O-linked_Glycosylation | QSLNPVLSLPINPAQ HHCCCHHCCCCCHHH | 32.12 | OGP |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of XYLT1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of XYLT1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of XYLT1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of XYLT1_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 615777 | Desbuquois dysplasia 2 (DBQD2) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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