XPA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: XPA_MOUSE
• UniProt AC: Q64267
• Protein Name: DNA repair protein complementing XP-A cells homolog
• Gene Name: Xpa
• Organism: Mus musculus (Mouse).
• Sequence Length: 272
• Subcellular Localization: Nucleus.
• Protein Description: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (By similarity)..
• Protein Sequence: MATAEEKQTSPEPVAADEPAQLPAAVRASVERKRQRALMLRQARLAARPYPAAAATGGVASVKAAPKMIDTKGGFILEEEEEKHEIGNIVHEPGPVMEFDYTICEECGKEFMDSYLMNHFDLPTCDSCRDADDKHKLITKTEAKQEYLLKDCDLEKREPALRFLVKKNPRHSQWGDMKLYLKLQVVKRALEVWGSQEALEDAKEVRQENREKMKQKKFDKKVKELRRAIRSSVWKRETTTHQHKYGPEENLEDDMYRKTCTLCGHELTYEKM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATAEEKQT ------CCCHHHCCC	18.60	-
9	Phosphorylation	ATAEEKQTSPEPVAA CCHHHCCCCCCCCCC	58.27	25521595
10	Phosphorylation	TAEEKQTSPEPVAAD CHHHCCCCCCCCCCC	25.44	22942356
195	Phosphorylation	RALEVWGSQEALEDA HHHHHHCCHHHHHHH	14.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Herc2	Q4U2R1	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of XPA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of XPA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of XPA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, AND MASSSPECTROMETRY.
PubMed: 15345747