XIRP2_RAT - dbPTM
XIRP2_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID XIRP2_RAT
UniProt AC Q71LX6
Protein Name Xin actin-binding repeat-containing protein 2
Gene Name Xirp2
Organism Rattus norvegicus (Rat).
Sequence Length 3302
Subcellular Localization Cell junction. Colocalizes with actin stress fibers.
Protein Description Protects actin filaments from depolymerization..
Protein Sequence MARYQAAVSRGDTRSFSANVMEESDLCTVPGGLAKMKRQFEKDEMTSTCNAFSEYQYQHESRSEQEAIHNRQEIRRNEEEVSKGHRTDVFKAEMMSHLEKHTEETNQASQFRQYVQETVIDTPEDEEIPKVSTKILKEQFEKTAQENFLYSDKETTTPAKCIKIENDSEETLKPSSAMGTSSYTSARQSKETSTSSYSNHSLTSTILAQEKGTPSGKMEEFPPPPPDVFQTPMDVTAFSQSPEFPSPPRRLPMPRDVYSKQRNLYELNRLYRHIHPELRKNLEKDYISEVSEIVSSHINSGNSISAGVQQARYVFENTNDSSQKDLSSERENLEWDEILKGEVQSIRWIFENQPLDSINQGFTDEAYTSKGIADQELIAGGDVKYTTWMFETQPIDALGVPSAGTEENTEKIPELAKGDVCTARWMFETRPLDSMNKMHEWEDETASTFIKDITGGDVKTVRYMFETQQLDQLGQLHSVDEMNLLQLRSELKEIKGNVKRSIKCFETQPLYVIRDGSGQMLEIKTVQREDIEKGDVRTARWMFETQPLDTIKQDITEIKVVRGISMEENVKGEVGRARWLFETQPLEKIKEESGEAVLKTEAVVGIDVSKKCWMFETQPLDTLKQSPDTESVSPEERIGGDVKTTKHLLETLPIEALKDSPDVGKLQKITASEEEKGDVKHQKWVFETQRLEDIREDKKEYTQTVKLEAVDRGHVKNYTHIFESNNLIKVDASHQIEVEGVTRGTVELNKSLFETTPLYAIQDHLGKYHQVKTVQQEEIVRGDVRSCRWLFETRPIDQFDESLHKFQIIRGISAQEIQAGNVKSARWLFETQPLDSIKYFSNVEETDSKTEQSTDIVKGDVKTCKWLFETQPMESLYEKASLMTNSEDIHKGDVRTCMWLFETQPLDAIKNDSEATVKLQTVKQEEIQGGDVRTACLLFETENLDNIQGGEGKETKPVEMDIESGDVSGMKYKFENQSLDSISCSSENVLNKIKTLKIEDIQKGNVLNCRWLFENQPIDMIKENQEGDGLVKTVTDIQGGDVRKGCFIFETFSLDEIKDESDVISTRQTNTEEVIKGDVKSYKMLFETQPLYAIQDQEGFYHEVTTVKKEETIHGDVRGTRWLFETKPLDSINASEDVYIIKSVTQEDIQKGDVSSVRYRFETQPLDMISDKSHNIMPTIDHIQGGNVQMNKQLFESEGGDKKNYVRTVSINEIQKGNVKTSTWLFETHSIDELGEVSTYENIKTVTQEDVQKGDVKQAVWLFENQTLDSIKELDESDTKITKEEIPPSDVKTTTWLFETTPIHEFNETRIEKEEIIGKSIKETLEDLYSQRVVEAPGIIIEADEVGDVRMAKYKLMNQRTPEIQKEEVIRADLGNIMMNLLSQRDCTKKEIFISEEEKGNVNFTKTQLLNRSMEFHAEKEEIVRGDVKQAIQKLFSEERCAKRGILIQEDEKGDVNMTIYCLLHENAGDKTKREDILGGDVRRTIHNLLSSASNDKISERTKIDASERGNVQFFTTCIETGALDYLKQLQTGSNETLTARKQEGEEEIIGGDVEGTKFLLKKRQSSIERTVSETDIIPGDVRNTVKVFMTEPQSASFKTAKEEIVKGDLKSTLNSLNQAMNQKVVAKTEDIMKDDKAAILKSLKESGGRQKEHKQSASISSDIGQAIECLEKATNTRTEILKKELILDDLKTSLRSLKEEQYSFKEVGKQGMVKDVLGFSERQELGIHPAAVQREKKSLLQPVPGPCEPAIRQQAGPGPLDEATQKSCHRSLTEERTEANLPKAPKGTVKIVIDREQNNDALEKSLRKMSNSEHRAMKNVLDMGDRRGVWTESKECLCSDDHMSKYVSASMSRKKSLKTKESENVRESKDDVSSTQSVDKTFRKQQTQNCELGKDHQKSQFQDSYAKNQKNTQNISMSAETQSYRPDPTQHPVSNPAGETLEMTRDFQKQALIRQEKQNSNKDMRKNDMGLQPLPVGKDAHSAPGVTVSGKNHKRTQAPDKKQRIDVCLESQDFLMKTNTSKELKMAMERSFNPVNLYPDCGVKENEDALPPPSPPPPPPSNASSEIEFPLPPPPPIMLLPEKNEFPPSSPTEKSRAELESLPTLPLPPPPGDEKSDQECLPTSLPPPPPTAPSQPAHLLSSSVLEHHSEAFLQQYSRKETLDSHQLHSQAKILTGKSPPPTLPKPKLPERIKAKMSQDSPSGELERSLSDVEIKTTLSKDQKSSLVAESREHTEAKQEVFRKSLGRKQLSISSANSLSQTVPEIPAPKEKQTAPLVKSHSFPSGSEQQSPKPYMRKFKTPLMIAEEKYRQQREELEKQRRESSCHSIIKTETQHRSLSEKEKETELQKAAEAMSTPRKDSDFTRAQPNLEPKSKAVIASECSESQLSTASALTVATERLQHVLAASDDKLTLRREGTQNSSDTLQSKTACEINQSHKECRTEQTFEQHVEKLPFPQTKPISPSFKVKTIRLPALDHTLTETDLSSERRVKQSEIDVQTSTKEMNKEIKKTEVSTQCDNKQSVAEKYFQLPKTEKRVTVQMPKDYAAKSHQSKLQTVPKKHGGLGEFDRGNVLGREGKNQDSSMSSTKESRVIVERKQEHLQDQSVPRLVQQKIIGESLDSRVQNFQQTQTQTSRIEHKELSQPYSEKKCLRDKDKQQKQVSSNTDDSKQEITQKQSSFSSVRESQQDGEKCAINILEFLRKREELQQILSRVKQFEADSNKSGLKTFQTLLNIAPVWLISEEKREYGVRVAMENNLEKVKEEIIHIKTQAEEMLVHCEHVIRTAMMASQTGKQKDKPTNLNEMPLKVSNVNLSSHKGTEQKESKIVEEKLASRQVATHSEAATHNPAKTYQEAKGDDSKMAPPSLKTRPPSPTFITIESTARRAETSTKSELSQSPKNNSCVEPLPRRPMEHTSRLPRTSTSPSPPRSRSEQLVRLKDTTARLAKGTIPCSPGTPVPVVEKRSEVVMSPATLRRQIKIESRGGDSPPTITIPVSVNHHVVSGSFRESVDAQEAVKKTEKTETYVHKDKKNSVSSAMPETESYDAVEIIRKVEGPHLSEHRERFEATNQTVQMAEHFLNGHENEVNRWFREFENGPVFGAKTERRAYANGEINHNMKQESHTFCKEEFGLESSETANFTGFSYRHPREHRAKAPATQPRVHSEARALNEHFLSVDAFDSQIVESQVATSSSRSSEAGRSGFDFKHAPPTYEDVIAGHILDIADSPTNLRRNFQKTWQESERVFKSVGYETSDAHATEMSRAFQEELAFLSETVGPRQGNLHNLSKDGLSNGVPRSRPAEFS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
517PhosphorylationLYVIRDGSGQMLEIK
EEEEECCCCCEEEEE		30.0926022182
565PhosphorylationIKVVRGISMEENVKG
EEEEECCCCCHHCCC		23.9828826663
633PhosphorylationSPDTESVSPEERIGG
CCCCCCCCHHHHCCC		35.5522673903
813PhosphorylationFQIIRGISAQEIQAG
CCEECCCCHHHHHCC		27.07-
863PhosphorylationIVKGDVKTCKWLFET
CCCCCHHHCHHHHHC		21.1116641100
875PhosphorylationFETQPMESLYEKASL
HHCCCCHHHHHHHHC		29.9616641100
877PhosphorylationTQPMESLYEKASLMT
CCCCHHHHHHHHCCC		25.3516641100
1109UbiquitinationHEVTTVKKEETIHGD
EEEEEEECEEEECCC		57.35-
1210PhosphorylationKNYVRTVSINEIQKG
CCEEEEEECCHHHCC		21.0528826663
1532PhosphorylationDYLKQLQTGSNETLT
HHHHHHCCCCCCCCE		51.6922673903
1534PhosphorylationLKQLQTGSNETLTAR
HHHHCCCCCCCCEEH		34.5822673903
1537PhosphorylationLQTGSNETLTARKQE
HCCCCCCCCEEHHHH		33.3922673903
1571PhosphorylationRQSSIERTVSETDII
CHHCCCCCCCCCCCC		18.6524945867
1573PhosphorylationSSIERTVSETDIIPG
HCCCCCCCCCCCCCC		33.8824945867
1575PhosphorylationIERTVSETDIIPGDV
CCCCCCCCCCCCCCH		25.6224945867
1930PhosphorylationQSYRPDPTQHPVSNP
CCCCCCCCCCCCCCC		47.0616641100
1935PhosphorylationDPTQHPVSNPAGETL
CCCCCCCCCCCCCCC		41.3616641100
2055PhosphorylationEDALPPPSPPPPPPS
CCCCCCCCCCCCCCC		56.6722673903
2062PhosphorylationSPPPPPPSNASSEIE
CCCCCCCCCCCCCCC		51.2922673903
2065PhosphorylationPPPPSNASSEIEFPL
CCCCCCCCCCCCCCC		32.5222673903
2066PhosphorylationPPPSNASSEIEFPLP
CCCCCCCCCCCCCCC		39.9322673903
2090PhosphorylationEKNEFPPSSPTEKSR
CCCCCCCCCCCHHHH		49.5422673903
2091PhosphorylationKNEFPPSSPTEKSRA
CCCCCCCCCCHHHHH		41.4322673903
2093PhosphorylationEFPPSSPTEKSRAEL
CCCCCCCCHHHHHHH		58.9822673903
2158PhosphorylationEAFLQQYSRKETLDS
HHHHHHHHHHCCCCH		32.32-
2198PhosphorylationERIKAKMSQDSPSGE
HHHHHHHCCCCCCCH		30.0822673903
2209PhosphorylationPSGELERSLSDVEIK
CCCHHHHHHHHCEEE		23.8922673903
2211PhosphorylationGELERSLSDVEIKTT
CHHHHHHHHCEEEEE		40.6428826663
2252PhosphorylationSLGRKQLSISSANSL
HHCCCCCCHHHCCCH		20.2428826663
2254PhosphorylationGRKQLSISSANSLSQ
CCCCCCHHHCCCHHC		21.7422673903
2255PhosphorylationRKQLSISSANSLSQT
CCCCCHHHCCCHHCC		29.7822673903
2619PhosphorylationQQKIIGESLDSRVQN
HHHHHHCCHHHHHHH		32.0622673903
2869PhosphorylationMAPPSLKTRPPSPTF
CCCCCCCCCCCCCCE		54.4222673903
2873PhosphorylationSLKTRPPSPTFITIE
CCCCCCCCCCEEEEE		38.9722673903
2875PhosphorylationKTRPPSPTFITIEST
CCCCCCCCEEEEECC		31.8222673903
2895PhosphorylationTSTKSELSQSPKNNS
CCCHHHHCCCCCCCC		25.2624945867
2897PhosphorylationTKSELSQSPKNNSCV
CHHHHCCCCCCCCCC		34.1724945867
2921PhosphorylationHTSRLPRTSTSPSPP
CCCCCCCCCCCCCCC		34.1224945867
2922PhosphorylationTSRLPRTSTSPSPPR
CCCCCCCCCCCCCCC		28.3224945867
2923PhosphorylationSRLPRTSTSPSPPRS
CCCCCCCCCCCCCCC		44.0024945867
2924PhosphorylationRLPRTSTSPSPPRSR
CCCCCCCCCCCCCCC		24.1324945867
2926PhosphorylationPRTSTSPSPPRSRSE
CCCCCCCCCCCCCCH		47.5124945867
2987PhosphorylationIESRGGDSPPTITIP
EECCCCCCCCEEEEE		35.7328826663
3225PhosphorylationHILDIADSPTNLRRN
HHHHHCCCCCHHHHH		25.3024945867
3227PhosphorylationLDIADSPTNLRRNFQ
HHHCCCCCHHHHHHH		51.3324945867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of XIRP2_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of XIRP2_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of XIRP2_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of XIRP2_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of XIRP2_RAT

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Related Literatures of Post-Translational Modification

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