dbPTM

XDH1_ARATH - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	XDH1_ARATH
UniProt AC	Q8GUQ8
Protein Name	Xanthine dehydrogenase 1
Gene Name	XDH1
Organism	Arabidopsis thaliana (Mouse-ear cress).
Sequence Length	1361
Subcellular Localization
Protein Description	Key enzyme involved in purine catabolism. Catalyzes the oxidation of hypoxanthine to xanthine and the oxidation of xanthine to urate. Regulates the level of ureides and plays an important role during plant growth and development, senescence and response to stresses. Possesses NADH oxidase activity and may contribute to the generation of superoxide anions in planta..
Protein Sequence	MGSLKKDGEIGDEFTEALLYVNGVRRVLPDGLAHMTLLEYLRDLGLTGTKLGCGEGGCGACTVMVSSYDRKSKTSVHYAVNACLAPLYSVEGMHVISIEGLGHRKLGLHPVQESLASSHGSQCGFCTPGFIMSMYSLLRSSKNSPSEEEIEECLAGNLCRCTGYRPIVDAFRVFAKSDDALYCGVSSLSLQDGSTICPSTGKPCSCGSKTTNEVASCNEDRFQSISYSDIDGAKYTDKELIFPPELLLRKLTPLKLRGNGGITWYRPVCLQNLLELKANYPDAKLLVGNTEVGIEMRLKRLQYQVLISVAQVPELNALNVNDNGIEVGSALRLSELLRLFRKIVKERPAHETSACKAFIEQLKWFAGTQIRNVACIGGNICTASPISDLNPLWMASRAEFRITNCNGDVRSIPAKDFFLGYRKVDMGSNEILLSVFLPWTRPLEYVKEFKQAHRRDDDIAIVNGGMRVFLEDKGQQLFVSDASIAYGGVAPLSLCARKTEEFLIGKNWNKDLLQDALKVIQSDVVIKEDAPGGMVEFRKSLTLSFFFKFFLWVSHNVNNANSAIETFPPSHMSAVQPVPRLSRIGKQDYETVKQGTSVGSSEVHLSARMQVTGEAEYTDDTPVPPNTLHAAFVLSKVPHARILSIDDSAAKSSSGFVGLFLAKDIPGDNMIGPIVPDEELFATDVVTCVGQVIGVVVADTHENAKTAAGKVDVRYEELPAILSIKEAINAKSFHPNTEKRLRKGDVELCFQSGQCDRVIEGEVQMGGQEHFYLEPNGSLVWTVDGGSEVHMISSTQAPQKHQKYVSHVLGLPMSKVVCKTKRIGGGFGGKETRSAFIAAAASVPSYLLNRPVKLILDRDVDMMITGHRHSFLGKYKVGFTNEGKILALDLEIYNNGGNSLDLSLSVLERAMFHSDNVYEIPHVRIVGNVCFTNFPSNTAFRGFGGPQGMLITENWIQRIAAELNKSPEEIKEMNFQVEGSVTHYCQTLQHCTLHQLWKELKVSCNFLKARREADEFNSHNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVYTDGTVLVTHGGVEMGQGLHTKVAQVAASAFNIPLSSVFVSETSTDKVPNASPTAASASSDMYGAAVLDACEQIIARMEPVASKHNFNTFTELVSACYFQRIDLSAHGFHIVPDLGFDWISGKGNAFRYYTYGAAFAEVEIDTLTGDFHTRAADIMLDLGYSLNPAIDVGQIEGAFVQGLGWVALEELKWGDAAHKWIKPGSLLTCGPGNYKIPSINDMPFNLNVSLLKGNPNTKAIHSSKAVGEPPFFLASSVFFAIKEAIKAARTEVGLTDWFPLESPATPERIRMACFDEFSAPFVNSDFYPNLSV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
47	Phosphorylation	YLRDLGLTGTKLGCG HHHHCCCCCCCCCCC	40.79	24894044
49	Phosphorylation	RDLGLTGTKLGCGEG HHCCCCCCCCCCCCC	20.19	24894044
252	Phosphorylation	ELLLRKLTPLKLRGN HHHHHHCCCCCCCCC	29.61	19376835

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of XDH1_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of XDH1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of XDH1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of XDH1_ARATH !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of XDH1_ARATH

Related Literatures of Post-Translational Modification