dbPTM

XCT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	XCT_HUMAN
UniProt AC	Q9UPY5
Protein Name	Cystine/glutamate transporter
Gene Name	SLC7A11
Organism	Homo sapiens (Human).
Sequence Length	501
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate..
Protein Sequence	MVRKPVVSTISKGGYLQGNVNGRLPSLGNKEPPGQEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGALSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELLIIRPAATAVISLAFGRYILEPFFIQCEIPELAIKLITAVGITVVMVLNSMSVSWSARIQIFLTFCKLTAILIIIVPGVMQLIKGQTQNFKDAFSGRDSSITRLPLAFYYGMYAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELLLSNAVAVTFSERLLGNFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEILSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYKCPDMHRPFKVPLFIPALFSFTCLFMVALSLYSDPFSTGIGFVITLTGVPAYYLFIIWDKKPRWFRIMSEKITRTLQIILEVVPEEDKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MVRKPVVSTIS ----CCCCCEEEEEC	30.65	21906983
8	Phosphorylation	MVRKPVVSTISKGGY CCCCCEEEEECCCCC	21.91	25159151
9	Phosphorylation	VRKPVVSTISKGGYL CCCCEEEEECCCCCE	20.05	25159151
11	Phosphorylation	KPVVSTISKGGYLQG CCEEEEECCCCCEEC	25.90	29514088
12	Ubiquitination	PVVSTISKGGYLQGN CEEEEECCCCCEECC	53.13	23000965
12	Ubiquitination	PVVSTISKGGYLQGN CEEEEECCCCCEECC	53.13	21890473
12	Sumoylation	PVVSTISKGGYLQGN CEEEEECCCCCEECC	53.13	-
15	Phosphorylation	STISKGGYLQGNVNG EEECCCCCEECCCCC	12.43	21945579
26	Phosphorylation	NVNGRLPSLGNKEPP CCCCCCCCCCCCCCC	54.20	22167270
30	Ubiquitination	RLPSLGNKEPPGQEK CCCCCCCCCCCCCHH	70.56	21906983
37	Ubiquitination	KEPPGQEKVQLKRKV CCCCCCHHHHHHHHH	27.65	21906983
41	Ubiquitination	GQEKVQLKRKVTLLR CCHHHHHHHHHHHHH	32.84	22817900
43	Ubiquitination	EKVQLKRKVTLLRGV HHHHHHHHHHHHHCC	37.67	23503661
51	Phosphorylation	VTLLRGVSIIIGTII HHHHHCCHHHHHHHH	15.76	-
222	Ubiquitination	KGQTQNFKDAFSGRD CCCCCCHHHHHCCCC	56.55	23000965
314	N-linked_Glycosylation	FSERLLGNFSLAVPI CCHHHHCCCCCHHHH	24.25	UniProtKB CARBOHYD
327	S-palmitoylation	PIFVALSCFGSMNGG HHHHHHHCCCCCCCC	4.69	29575903
481	Phosphorylation	PRWFRIMSEKITRTL CCCHHHHCHHHHHHH	33.11	22673903
483	Ubiquitination	WFRIMSEKITRTLQI CHHHHCHHHHHHHHH	41.91	21906983
500	Ubiquitination	EVVPEEDKL------ HCCCCCCCC------	60.42	29901268

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
26	S	Phosphorylation	Kinase	AKT1	P31749	PSP
26	S	Phosphorylation	Kinase	MTOR	P42345	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of XCT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of XCT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of XCT_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB06151	Acetylcysteine
DB00138	L-Cystine
DB00740	Riluzole
DB01098	Rosuvastatin
DB00795	Sulfasalazine
DB08834	Tauroursodeoxycholic acid

Regulatory Network of XCT_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, AND MASSSPECTROMETRY.	17081983 [Abstract]