X3CL1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: X3CL1_RAT
• UniProt AC: O55145
• Protein Name: Fractalkine
• Gene Name: Cx3cl1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 393
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .; Processed fractalkine: Secreted .
• Protein Description: Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium..
• Protein Sequence: MAPSQLAWLLRLAAFFHLCTLLAGQHLGMTKCNITCHKMTSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLDHQTAALTRNGGKFEKRVDNVTPRITSATRGLSPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPAAVTGSSPSTSKAQDAGLAAKPQSTGISEVAAVSTTIWPSSAVYQSGSSLWAEEKATESPPTIALSTQASTTSSPKQNVGSEGQPPWVQEQDSTPEKSPGPEETNPVHTDIFQDRGPGSTVHPSVAPTSSEKTPSPELVASGSQAPKVEEPIHATADPQKLSVFITPVPDSQAATRRQAVGLLAFLGLLFCLGVAMFAYQSLQGCPRKMAGEMVEGLRYVPRSCGSNSYVLVPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	N-linked_Glycosylation	HLGMTKCNITCHKMT HHCCCCCCEEEECCC	33.87	-
111	Phosphorylation	EKRVDNVTPRITSAT EEEECCCCHHCHHCC	17.07	28432305
138	Phosphorylation	SATVEDLTLEPTAIS CCEECCCCCCCCCCC	41.20	23984901
142	Phosphorylation	EDLTLEPTAISQEAR CCCCCCCCCCCHHHC	27.52	23984901
145	Phosphorylation	TLEPTAISQEARRPM CCCCCCCCHHHCCCC	21.36	23984901
367	Ubiquitination	SLQGCPRKMAGEMVE HHCCCCHHHHHHHCC	20.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of X3CL1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of X3CL1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of X3CL1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of X3CL1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.