dbPTM

WWP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WWP1_MOUSE
UniProt AC	Q8BZZ3
Protein Name	NEDD4-like E3 ubiquitin-protein ligase WWP1
Gene Name	Wwp1
Organism	Mus musculus (Mouse).
Sequence Length	918
Subcellular Localization	Cytoplasm . Cell membrane Peripheral membrane protein . Nucleus .
Protein Description	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF (By similarity). Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7..
Protein Sequence	MATASPRSDTSDIHSGRLQLKVTVSSAKLKRKKNWFGTAIYTEVIVDGEVKKTAKSSSSSNPKWDEQLIVNVTPQTTLEFRVWSHHTLKADALLGKATVDLKQVLLTHNRKLEKVKEQLKLSLENKNGIVQTGELTVVLDGLVIEQEPVTNRSSSPPIEIQQNGDALHENGDPATRTTPRLPVEGTIGIDNHVSTNTVVPNSCCSHVVNGENTPSSPSQVAARPKNAPAPKPVTSAPTSDTVNGESSSVLADNTSTMGTLLPSEDTTSTSNCTSTTTQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNNSVFDKVRQPEGCVEPLRPQSGNTNTEALPSGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPPGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQWQSQRNQLQGAMQQFNQRYLYSASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQGLPNEEPLPEGWEIRYTREGVRYFVDHNTRTTTFKDPRNGKSSVTKGGPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDNNIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRHYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MATASPRSDTSDIHS CCCCCCCCCCCCCCC	48.93	30635358
10	Phosphorylation	TASPRSDTSDIHSGR CCCCCCCCCCCCCCE	29.55	30635358
11	Phosphorylation	ASPRSDTSDIHSGRL CCCCCCCCCCCCCEE	39.29	30635358
25	Phosphorylation	LQLKVTVSSAKLKRK EEEEEEECHHHHHCC	18.40	-
26	Phosphorylation	QLKVTVSSAKLKRKK EEEEEECHHHHHCCC	25.70	-
153	Phosphorylation	QEPVTNRSSSPPIEI ECCCCCCCCCCCEEE	36.92	26643407
154	Phosphorylation	EPVTNRSSSPPIEIQ CCCCCCCCCCCEEEE	43.56	26643407
155	Phosphorylation	PVTNRSSSPPIEIQQ CCCCCCCCCCEEEEE	35.62	30635358
216	Phosphorylation	NGENTPSSPSQVAAR CCCCCCCCHHHHHCC	29.76	23384938
320	Phosphorylation	DSDSRNNSVFDKVRQ CCCCCCCCHHHHHCC	27.92	22210690
324	Ubiquitination	RNNSVFDKVRQPEGC CCCCHHHHHCCCCCC	28.05	-
394	Phosphorylation	VDDRGRVYYVDHNTR ECCCCCEEEEECCCC	9.08	26643407
395	Phosphorylation	DDRGRVYYVDHNTRT CCCCCEEEEECCCCE	9.13	26643407
400	Phosphorylation	VYYVDHNTRTTTWQR EEEEECCCCEEEEEC	26.44	26643407
402	Phosphorylation	YVDHNTRTTTWQRPT EEECCCCEEEEECCC	26.92	26643407
403	Phosphorylation	VDHNTRTTTWQRPTM EECCCCEEEEECCCH	23.81	26643407
404	Phosphorylation	DHNTRTTTWQRPTME ECCCCEEEEECCCHH	20.98	26643407
439	Phosphorylation	QFNQRYLYSASMLAA HHHHHHHHHHHHHHH	8.02	22817900
464	Phosphorylation	GWEKRVDSTDRVYFV CHHHCCCCCCEEEEE	29.38	29899451
465	Phosphorylation	WEKRVDSTDRVYFVN HHHCCCCCCEEEEEE	24.30	29899451
850	S-palmitoylation	LQFVTGTCRLPLGGF HHHHHCCCCCCCCHH	4.44	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Wwp1	Q8BZZ3	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WWP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WWP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of WWP1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WWP1_MOUSE

Related Literatures of Post-Translational Modification