dbPTM

WUHO_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WUHO_DROME
UniProt AC	Q9W415
Protein Name	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho {ECO:0000255\|HAMAP-Rule:MF_03056}
Gene Name	wuho {ECO:0000255\|HAMAP-Rule:MF_03056}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	424
Subcellular Localization	Nucleus . Localized to the nuclei of nurse cells, follicle cells and oocytes at early stages, from germarium to stage 4 egg chambers. Also present in the nuclei of spermatocytes and in the apical cells of the testes.
Protein Description	Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis..
Protein Sequence	MCTTISFAEPEIVLGHGRRVLFVNPDDLQIFKEIELPPDLGLKGHTSQSQESCTAAAAASTATAASGQAPGGKEQQLANQPEEGGTSASASGLGCATSTSVQNVAYSPDGQLLAVTTSGKQKALLLYRSRPENARLLSARPLARASSALRFCSDSSSILVTDKTGDCYQYDCVEVEAPPRLLLGHLSVVYDILWSEDQQHIITCDRDDKIRVTNYPATFDIHSYCLGHREFVSGLALLTEQHIASASGDKTLRVWNYIQGKELLQHELPAPAVRLLVRQLEPEKVFQAAVLFYEHVDALGLYRLERSSDDTWSVTATQLVCAEAGSWSISNFTLTSDRIYITGAENERLSLRVYDIATGQPASSGVPEGWLKMVLDGLGANEEGAPPFIPEDLSVWFKKRFDNVSDYLERKKRRIEEQQQQKCG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	DLGLKGHTSQSQESC CCCCCCCCCCCHHHH	36.81	21082442
49	Phosphorylation	LKGHTSQSQESCTAA CCCCCCCCHHHHHHH	35.37	29892262
52	Phosphorylation	HTSQSQESCTAAAAA CCCCCHHHHHHHHHH	14.77	29892262
60	Phosphorylation	CTAAAAASTATAASG HHHHHHHHHHHHHCC	17.53	29892262

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WUHO_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WUHO_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WUHO_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of WUHO_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WUHO_DROME

Related Literatures of Post-Translational Modification