dbPTM

WSB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WSB2_MOUSE
UniProt AC	O54929
Protein Name	WD repeat and SOCS box-containing protein 2
Gene Name	Wsb2
Organism	Mus musculus (Mouse).
Sequence Length	404
Subcellular Localization
Protein Description	May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
Protein Sequence	MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCVVKLVPWPLEEQFIPKGFEAKSRSSKNDPKGRGSLKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQAPDVSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHTQLEPTMDDSDVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNGLCCTFFPHGGIIATGTRDGHVQFWTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	RGSLKEKTLDCGQIV CCCCCCCEECCCCEE	28.99	25777480
100	Phosphorylation	IVWGLAFSPWPSPPS EEEEEECCCCCCCCC	22.05	25777480
104	Phosphorylation	LAFSPWPSPPSRKLW EECCCCCCCCCHHHH	45.64	25777480
107	Phosphorylation	SPWPSPPSRKLWARH CCCCCCCCHHHHHHH	45.49	25777480
370	Ubiquitination	PRVLSSLKHLCRKAL HHHHHHHHHHHHHHH	36.16	-
374	Dimethylation	SSLKHLCRKALRSFL HHHHHHHHHHHHHHH	33.37	-
374	Methylation	SSLKHLCRKALRSFL HHHHHHHHHHHHHHH	33.37	18964275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WSB2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WSB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WSB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of WSB2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WSB2_MOUSE

Related Literatures of Post-Translational Modification