dbPTM

WNT6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WNT6_HUMAN
UniProt AC	Q9Y6F9
Protein Name	Protein Wnt-6
Gene Name	WNT6
Organism	Homo sapiens (Human).
Sequence Length	365
Subcellular Localization	Secreted, extracellular space, extracellular matrix.
Protein Description	Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Together with CAV1 may promote chemoresistance of gastric cancer cells to DNA-damaging anthracycline drugs through the activation of the canonical Wnt receptor signaling pathway..
Protein Sequence	MLPPLPSRLGLLLLLLLCPAHVGGLWWAVGSPLVMDPTSICRKARRLAGRQAELCQAEPEVVAELARGARLGVRECQFQFRFRRWNCSSHSKAFGRILQQDIRETAFVFAITAAGASHAVTQACSMGELLQCGCQAPRGRAPPRPSGLPGTPGPPGPAGSPEGSAAWEWGGCGDDVDFGDEKSRLFMDARHKRGRGDIRALVQLHNNEAGRLAVRSHTRTECKCHGLSGSCALRTCWQKLPPFREVGARLLERFHGASRVMGTNDGKALLPAVRTLKPPGRADLLYAADSPDFCAPNRRTGSPGTRGRACNSSAPDLSGCDLLCCGRGHRQESVQLEENCLCRFHWCCVVQCHRCRVRKELSLCL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	N-linked_Glycosylation	QFRFRRWNCSSHSKA EEEECCCCCCHHHHH	17.62	UniProtKB CARBOHYD
228	O-palmitoleoylation	ECKCHGLSGSCALRT CCCCCCCCCCCHHHH	33.00	-
263	Phosphorylation	GASRVMGTNDGKALL CCCCEECCCCHHHHH	16.43	-
275	Phosphorylation	ALLPAVRTLKPPGRA HHHHHHHCCCCCCCC	32.32	-
302	Phosphorylation	APNRRTGSPGTRGRA CCCCCCCCCCCCCCC	21.39	-
311	N-linked_Glycosylation	GTRGRACNSSAPDLS CCCCCCCCCCCCCCC	37.71	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WNT6_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WNT6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WNT6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of WNT6_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WNT6_HUMAN

Related Literatures of Post-Translational Modification