| UniProt ID | WNT3_HUMAN | |
|---|---|---|
| UniProt AC | P56703 | |
| Protein Name | Proto-oncogene Wnt-3 | |
| Gene Name | WNT3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 355 | |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix . Secreted . | |
| Protein Description | Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. [PubMed: 26902720 Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge (By similarity Required for normal embryonic development, and especially for limb development] | |
| Protein Sequence | MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 90 | N-linked_Glycosylation | QFRGRRWNCTTIDDS HHCCCCCCCEECCHH | 16.08 | UniProtKB CARBOHYD | |
| 90 | N-linked_Glycosylation | QFRGRRWNCTTIDDS HHCCCCCCCEECCHH | 16.08 | 11604997 | |
| 212 | O-palmitoleoylation | KCKCHGLSGSCEVKT EEEECCCCCCCEEEE | 33.00 | - | |
| 238 | Phosphorylation | GDFLKDKYDSASEMV HHHHHHHCCCHHHHH | 25.84 | 21955146 | |
| 240 | Phosphorylation | FLKDKYDSASEMVVE HHHHHCCCHHHHHHH | 30.51 | 21955146 | |
| 242 | Phosphorylation | KDKYDSASEMVVEKH HHHCCCHHHHHHHHH | 30.12 | 21955146 | |
| 264 | Phosphorylation | ETLRAKYSLFKPPTE HHHHHHHHCCCCCCH | 26.99 | 24719451 | |
| 301 | N-linked_Glycosylation | GTRDRTCNVTSHGID CCCCCCCCCCCCCCC | 39.22 | UniProtKB CARBOHYD | |
| 301 | N-linked_Glycosylation | GTRDRTCNVTSHGID CCCCCCCCCCCCCCC | 39.22 | 11604997 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WNT3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WNT3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WNT3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of WNT3_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 273395 | Tetraamelia syndrome, autosomal recessive (TETAMS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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