| UniProt ID | WNT2B_HUMAN | |
|---|---|---|
| UniProt AC | Q93097 | |
| Protein Name | Protein Wnt-2b | |
| Gene Name | WNT2B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 391 | |
| Subcellular Localization | Secreted, extracellular space, extracellular matrix . Secreted . | |
| Protein Description | Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.. | |
| Protein Sequence | MLRPGGAEEAAQLPLRRASAPVPVPSPAAPDGSRASARLGLACLLLLLLLTLPARVDTSWWYIGALGARVICDNIPGLVSRQRQLCQRYPDIMRSVGEGAREWIRECQHQFRHHRWNCTTLDRDHTVFGRVMLRSSREAAFVYAISSAGVVHAITRACSQGELSVCSCDPYTRGRHHDQRGDFDWGGCSDNIHYGVRFAKAFVDAKEKRLKDARALMNLHNNRCGRTAVRRFLKLECKCHGVSGSCTLRTCWRALSDFRRTGDYLRRRYDGAVQVMATQDGANFTAARQGYRRATRTDLVYFDNSPDYCVLDKAAGSLGTAGRVCSKTSKGTDGCEIMCCGRGYDTTRVTRVTQCECKFHWCCAVRCKECRNTVDVHTCKAPKKAEWLDQT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 19 | Phosphorylation | QLPLRRASAPVPVPS CCCCCCCCCCCCCCC | 31.15 | 23312004 | |
| 117 | N-linked_Glycosylation | QFRHHRWNCTTLDRD HHHHCCCCCEECCCC | 17.14 | 18780401 | |
| 243 | O-palmitoleoylation | ECKCHGVSGSCTLRT EEEECCCCCCCHHHH | 29.58 | - | |
| 269 | Phosphorylation | GDYLRRRYDGAVQVM HHHHHHHCCCCEEEE | 19.54 | 24043423 | |
| 278 | Phosphorylation | GAVQVMATQDGANFT CCEEEEEECCCCCCH | 14.75 | 24043423 | |
| 283 | N-linked_Glycosylation | MATQDGANFTAARQG EEECCCCCCHHHHHH | 40.09 | 18780401 | |
| 283 | N-linked_Glycosylation | MATQDGANFTAARQG EEECCCCCCHHHHHH | 40.09 | 18780401 | |
| 285 | Phosphorylation | TQDGANFTAARQGYR ECCCCCCHHHHHHHH | 21.15 | 24043423 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WNT2B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WNT2B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WNT2B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of WNT2B_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Identification of N-linked glycoproteins in human milk by hydrophilicinteraction liquid chromatography and mass spectrometry."; Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.; Proteomics 8:3833-3847(2008). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-117 AND ASN-283, AND MASSSPECTROMETRY. | |
