dbPTM

WN10A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WN10A_HUMAN
UniProt AC	Q9GZT5
Protein Name	Protein Wnt-10a
Gene Name	WNT10A
Organism	Homo sapiens (Human).
Sequence Length	417
Subcellular Localization	Secreted, extracellular space, extracellular matrix . Secreted .
Protein Description	Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays a role in normal ectoderm development. [PubMed: 17847007]
Protein Sequence	MGSAHPRPWLRLRPQPQPRPALWVLLFFLLLLAAAMPRSAPNDILDLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRDQRWNCSSLETRNKIPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCDASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPALPTASPGLQDSWEWGGCSPDMGFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGALLRSRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGAPGPRRRASPADLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSAGSDGCGSMCCGRGHNILRQTRSERCHCRFHWCCFVVCEECRITEWVSVCK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	LAAAMPRSAPNDILD HHHHCCCCCCCCCCC	42.05	22210691
59	Phosphorylation	EPVLNANTVCLTLPG CCCCCCCEEEEECCC	15.36	-
63	Phosphorylation	NANTVCLTLPGLSRR CCCEEEEECCCCCHH	26.27	22210691
68	Phosphorylation	CLTLPGLSRRQMEVC EEECCCCCHHHEEHH	31.19	22210691
106	N-linked_Glycosylation	QFRDQRWNCSSLETR HHHCCCCCCCCCCCC	20.27	UniProtKB CARBOHYD
268	O-palmitoleoylation	KCKCHGTSGSCQLKT HCCCCCCCCCCCCEE	33.05	-
319	O-linked_Glycosylation	PGPAGAPSPAPGAPG CCCCCCCCCCCCCCC	32.91	OGP
363	N-linked_Glycosylation	GTVGRLCNKSSAGSD CHHHHHCCCCCCCCC	52.41	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WN10A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WN10A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WN10A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of WN10A_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WN10A_HUMAN

Related Literatures of Post-Translational Modification