dbPTM

WIPF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WIPF1_MOUSE
UniProt AC	Q8K1I7
Protein Name	WAS/WASL-interacting protein family member 1
Gene Name	Wipf1
Organism	Mus musculus (Mouse).
Sequence Length	493
Subcellular Localization	Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle . Vesicle surfaces and along actin tails. Colocalizes with actin stress fibers. When coexpressed with WASL, no longer associated with actin filaments but accumulated in perinuclear
Protein Description	Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity). Plays a role in the formation of cell ruffles..
Protein Sequence	MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGKKLKKTVTNDRSAPILDKPKGAGASAGGYGGGGGGGGGGGGGGGGSGGNFGGGGPPGLGGLFQAGMPKLRSTANRDNDSGGSRPPILPPGGRATSAKPFSPPSGPGRFPAPSPGHRSGPPEPPRNRMPPPRPDVGSKPDSLPPPVPNTPRPVPSSLHNRGSPAGLGAPRPPFPGNRGAAFGAGSARQNPSGSSSPFPRPPLPPTPSRALDDKPPPPPPPVGNRPSMHREAVPPPPSQTSKPPVPSTPRPGLGSQAPPPPPPPSRPGPPPLPPASNDEIPRLPQRNLSLTSSAPPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPINRNGSTARALPATPQLPSRSGMDSPRSGPRPPLPPDRPGAGAPPPPPPSTSVRNGFQDSSCEDEWESRFYFHPISDLPPPEPYVPTTKTYPSKLARNESRSGSNRRERGAPPLPPIPR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Asymmetric dimethylarginine	NKTEQAGRNALLSDI CHHHHHHHHHHHHHH	28.41	-
33	Methylation	NKTEQAGRNALLSDI CHHHHHHHHHHHHHH	28.41	24129315
126	Methylation	DNDSGGSRPPILPPG CCCCCCCCCCCCCCC	44.27	24129315
135	Methylation	PILPPGGRATSAKPF CCCCCCCCCCCCCCC	40.38	24129315
143	Phosphorylation	ATSAKPFSPPSGPGR CCCCCCCCCCCCCCC	44.41	19144319
146	Phosphorylation	AKPFSPPSGPGRFPA CCCCCCCCCCCCCCC	62.09	25266776
155	Phosphorylation	PGRFPAPSPGHRSGP CCCCCCCCCCCCCCC	45.69	25266776
197	Phosphorylation	NTPRPVPSSLHNRGS CCCCCCCHHHCCCCC	45.85	29176673
198	Phosphorylation	TPRPVPSSLHNRGSP CCCCCCHHHCCCCCC	27.81	29176673
227	Phosphorylation	GAAFGAGSARQNPSG CCCCCCCCCCCCCCC	21.53	26824392
268	Phosphorylation	PPVGNRPSMHREAVP CCCCCCCCCCCCCCC	24.80	19144319
330	Phosphorylation	RLPQRNLSLTSSAPP CCCCCCCCCCCCCCC	32.90	26824392
332	Phosphorylation	PQRNLSLTSSAPPLP CCCCCCCCCCCCCCC	19.77	20469934
333	Phosphorylation	QRNLSLTSSAPPLPS CCCCCCCCCCCCCCC	29.78	28833060
334	Phosphorylation	RNLSLTSSAPPLPSP CCCCCCCCCCCCCCC	39.29	28833060
340	Phosphorylation	SSAPPLPSPGRSGPL CCCCCCCCCCCCCCC	47.90	26824392
380	Phosphorylation	PPINRNGSTARALPA CCCCCCCCCCCCCCC	23.57	29514104
388	Phosphorylation	TARALPATPQLPSRS CCCCCCCCCCCCCCC	15.04	28833060
399	Phosphorylation	PSRSGMDSPRSGPRP CCCCCCCCCCCCCCC	17.20	29514104
434	Phosphorylation	VRNGFQDSSCEDEWE CCCCCCCCCCCCHHH	26.55	30635358
435	Phosphorylation	RNGFQDSSCEDEWES CCCCCCCCCCCHHHH	29.80	30635358
445	Phosphorylation	DEWESRFYFHPISDL CHHHHCCEEEEHHHC	10.40	25367039
478	Phosphorylation	RNESRSGSNRRERGA CCCCCCCCCCCCCCC	28.54	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WIPF1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WIPF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WIPF1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of WIPF1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WIPF1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Identification of phosphoproteins and their phosphorylation sites inthe WEHI-231 B lymphoma cell line."; Shu H., Chen S., Bi Q., Mumby M., Brekken D.L.; Mol. Cell. Proteomics 3:279-286(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-332 AND SER-340, ANDMASS SPECTROMETRY.	14729942 [Abstract]