WFS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WFS1_MOUSE
• UniProt AC: P56695
• Protein Name: Wolframin
• Gene Name: Wfs1
• Organism: Mus musculus (Mouse).
• Sequence Length: 890
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store..
• Protein Sequence: MNSGTPPPSPSGPPPPPAPQPQARARLNATASLEQDKIEPPRAPRPQADPSAGRSAGEAAAPEPRAPQTGSREETDRAGPMKADVEIPFEEVLEKAKAGDPKAQTEVGKHYLRLANDADEELNSCSAVAWLILAAKQGRREAVKLLRRCLADRKGITSENEAEVKQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVSELLENVGQVNEQDGGAQPGPVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGIIPTNLFLQDEDEDEDELAGKSPEDLPLRQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTIVPTHHINALIFFFIISNLTIDFFAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDVEQAEVNFGWNHLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVISTFFTVTSYMSLSSSAEPYTRRALVTEVAAGLLSLLPTVPVDWRFLKVLGQTFFTVPVGHFIILNVSLPCLLYVYLFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIGYFLFLFALPILVAGLALMGTVQFARWFLSLDLTKIMVTTVICGVPLLFRWWTKANFSVMGMVKSLTKSSMVKLILVWLTAILLFCWFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKETNMARTQILCSHLEGHRVTWTGRFKYVRVTEIDNSAESAINMLPFFLGDWMRCLYGEAYPSCSSGNTSTAEEELCRLKQLAKHPCHIKKFDRYKFEITVGMPFGTNGNRGHEEDDITKDIVLRASSEFKDVLLNLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMTQLSPARRHVKIEQDWRSTVHGALKFAFDFFFFPFLSAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MNSGTPPP -------CCCCCCCC	8.98	-
3	Phosphorylation	-----MNSGTPPPSP -----CCCCCCCCCC	42.62	25619855
5	Phosphorylation	---MNSGTPPPSPSG ---CCCCCCCCCCCC	32.23	26824392
9	Phosphorylation	NSGTPPPSPSGPPPP CCCCCCCCCCCCCCC	37.16	26824392
11	Phosphorylation	GTPPPSPSGPPPPPA CCCCCCCCCCCCCCC	69.17	25619855
30	Phosphorylation	ARARLNATASLEQDK HHHHHCCCCCCCCCC	18.73	24899341
32	Phosphorylation	ARLNATASLEQDKIE HHHCCCCCCCCCCCC	28.25	25521595
51	Phosphorylation	PRPQADPSAGRSAGE CCCCCCCCCCCCCCH	43.85	29899451
55	Phosphorylation	ADPSAGRSAGEAAAP CCCCCCCCCCHHCCC	39.44	24899341
69	Phosphorylation	PEPRAPQTGSREETD CCCCCCCCCCHHHCC	35.75	29899451
71	Phosphorylation	PRAPQTGSREETDRA CCCCCCCCHHHCCCC	39.65	29899451
75	Phosphorylation	QTGSREETDRAGPMK CCCCHHHCCCCCCCC	26.49	29899451
109	Acetylation	KAQTEVGKHYLRLAN HHHHHHHHHHHHHCC	33.96	7713301
144	Malonylation	QGRREAVKLLRRCLA CCHHHHHHHHHHHHH	49.18	26320211
157	Phosphorylation	LADRKGITSENEAEV HHHCCCCCCCCHHHH	38.36	27742792
158	Phosphorylation	ADRKGITSENEAEVK HHCCCCCCCCHHHHH	36.18	25521595
236	Phosphorylation	RMLERLVSSESKNYI HHHHHHHCCCCCCEE	32.74	25521595
237	Phosphorylation	MLERLVSSESKNYIA HHHHHHCCCCCCEEE	38.11	24453211
239	Phosphorylation	ERLVSSESKNYIALD HHHHCCCCCCEEEHH	28.31	23140645
280	Phosphorylation	EDELAGKSPEDLPLR HHHHCCCCHHHCCHH	32.38	27180971
621	Phosphorylation	WWTKANFSVMGMVKS HHHHCCCCHHHHHHH	15.82	22817900
628	Phosphorylation	SVMGMVKSLTKSSMV CHHHHHHHCCHHHHH	29.84	22817900
630	Phosphorylation	MGMVKSLTKSSMVKL HHHHHHCCHHHHHHH	35.65	20531401
663	N-linked_Glycosylation	SEGMKVYNSTLTWQQ HCCCEEECCEEEHHH	31.35	15522226
748	N-linked_Glycosylation	YPSCSSGNTSTAEEE CCCCCCCCCCHHHHH	32.57	15522226
780	Phosphorylation	DRYKFEITVGMPFGT CCCEEEEEEECCCCC	12.10	22817900
787	Phosphorylation	TVGMPFGTNGNRGHE EEECCCCCCCCCCCC	40.09	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WFS1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WFS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WFS1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WFS1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, AND MASSSPECTROMETRY.
PubMed: 17114649