WEE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WEE2_HUMAN
• UniProt AC: P0C1S8
• Protein Name: Wee1-like protein kinase 2
• Gene Name: WEE2
• Organism: Homo sapiens (Human).
• Sequence Length: 567
• Subcellular Localization: Nucleus .
• Protein Description: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity)..
• Protein Sequence: MDDKDIDKELRQKLNFSYCEETEIEGQKKVEESREASSQTPEKGEVQDSEAKGTPPWTPLSNVHELDTSSEKDKESPDQILRTPVSHPLKCPETPAQPDSRSKLLPSDSPSTPKTMLSRLVISPTGKLPSRGPKHLKLTPAPLKDEMTSLALVNINPFTPESYKKLFLQSGGKRKIRGDLEEAGPEEGKGGLPAKRCVLRETNMASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSINKPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLPTNGAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALARNTVLRPSLGKTEELQQQLNLEKFKTATLERELREAQQAQSPQGYTHHGDTGVSGTHTGSRSTKRLVGGKSARSSSFTSGEREPLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	SSEKDKESPDQILRT CCCCCCCCHHHCCCC	39.25	-
83	Phosphorylation	SPDQILRTPVSHPLK CHHHCCCCCCCCCCC	25.29	-
102	Phosphorylation	PAQPDSRSKLLPSDS CCCCCCHHCCCCCCC	31.44	-
123	Phosphorylation	MLSRLVISPTGKLPS HHHHHEECCCCCCCC	14.66	22496350
139	Phosphorylation	GPKHLKLTPAPLKDE CCCCCCCCCCCCCCC	18.80	28060719
202	Phosphorylation	KRCVLRETNMASRYE HHHHHHCCCHHHHHH	24.70	30622161
206	Phosphorylation	LRETNMASRYEKEFL HHCCCHHHHHHHHEE	25.32	30622161
208	Phosphorylation	ETNMASRYEKEFLEV CCCHHHHHHHHEEEE	28.94	30622161
225	Phosphorylation	IGVGEFGTVYKCIKR ECCCCCHHHHHHHHH	26.44	-
389	Acetylation	GHATSINKPKVEEGD CCCCCCCCCCCCCCC	44.54	7666013
461	Phosphorylation	ELSESFSSLLKNMIQ HHHHHHHHHHHHHCC	35.39	24719451
509	Phosphorylation	LEKFKTATLERELRE HHHHHHHHHHHHHHH	34.09	20058876
526	Phosphorylation	QAQSPQGYTHHGDTG HCCCCCCCCCCCCCC	9.54	22210691
527	Phosphorylation	AQSPQGYTHHGDTGV CCCCCCCCCCCCCCC	17.77	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WEE2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WEE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WEE2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of WEE2_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.