WDTC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDTC1_MOUSE
• UniProt AC: Q80ZK9
• Protein Name: WD and tetratricopeptide repeats protein 1
• Gene Name: Wdtc1
• Organism: Mus musculus (Mouse).
• Sequence Length: 677
• Protein Description: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex..
• Protein Sequence: MAKVNITRDLIRRQVKERGALSFERRYHVTDPFIRRLGLEAELQGHSGCVNCLEWNEKGDLLASGSDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHAGDRILITGAADSKVHVHDLTVKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIRQYDLRENSKHSEVLIDLTEYCGPMVEAKCLTVNPQDNNCLAVGASGPFVRLYDIRMIHNHRKSMRQSPSAGVHTFCDRQKPLPDGAAQYYVAGHLPVKLPDYNSRLRVLVATYVTFSPNGTELLVNMGGEQVYLFDLTYKQRPYTFLLPRKCHSVEVQNGKMSTNGVSNGVSNGLHLHSNGFRLPESKGCISPQVELPPYLERVKQQANEAFACQQWTQAIQLYSQAVQKAPHNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVAEALECLDDFKGKFPEQAHSSACDALGRDITAALFSKSDGEEKKAAGGGGGPVRLRSTSRKDSISEDEMVLRERSYDYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWEKETTNLVRVLQGDESIVNCLQPHPSYCFLATSGIDPVVRLWNPRPESEDLTGRVVEDMEGASQANQRRMNANPLEAMLLDMGYRITGLSSGGAGASDDEDSAEGQVQCRPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
223	Phosphorylation	MIHNHRKSMRQSPSA HHHHCCHHHHCCCCC	21.10	26643407
225	Methylation	HNHRKSMRQSPSAGV HHCCHHHHCCCCCCC	40.70	18967813
227	Phosphorylation	HRKSMRQSPSAGVHT CCHHHHCCCCCCCCE	15.51	25266776
229	Phosphorylation	KSMRQSPSAGVHTFC HHHHCCCCCCCCEEC	42.79	26643407
238	Methylation	GVHTFCDRQKPLPDG CCCEECCCCCCCCCC	47.83	18967823
324	Phosphorylation	VQNGKMSTNGVSNGV EECCEECCCCCCCCC	32.28	22817900
328	Phosphorylation	KMSTNGVSNGVSNGL EECCCCCCCCCCCCC	29.30	21183079
348	Ubiquitination	GFRLPESKGCISPQV CEECCCCCCCCCCCC	57.02	-
352	Phosphorylation	PESKGCISPQVELPP CCCCCCCCCCCCCCH	17.23	26745281
401	Ubiquitination	NAMLYGNRAAAYMKR CCHHCCHHHHHHHHH	22.65	27667366
423	Ubiquitination	DALRDCLKAISLNPC HHHHHHHHHHCCCCH	50.43	-
484	Ubiquitination	DITAALFSKSDGEEK HHHHHHHCCCCCCCC	31.90	27667366
485	Ubiquitination	ITAALFSKSDGEEKK HHHHHHCCCCCCCCC	45.27	27667366
505	Phosphorylation	GGPVRLRSTSRKDSI CCCCCCCCCCCCCCC	35.01	23984901
506	Phosphorylation	GPVRLRSTSRKDSIS CCCCCCCCCCCCCCC	26.56	23984901
507	Phosphorylation	PVRLRSTSRKDSISE CCCCCCCCCCCCCCH	38.28	23984901
509	Ubiquitination	RLRSTSRKDSISEDE CCCCCCCCCCCCHHH	56.44	-
511	Phosphorylation	RSTSRKDSISEDEMV CCCCCCCCCCHHHHH	30.92	25521595
513	Phosphorylation	TSRKDSISEDEMVLR CCCCCCCCHHHHHHH	42.84	25521595
652	Phosphorylation	LDMGYRITGLSSGGA HHCCCCEECCCCCCC	24.07	25293948
655	Phosphorylation	GYRITGLSSGGAGAS CCCEECCCCCCCCCC	28.43	25293948
656	Phosphorylation	YRITGLSSGGAGASD CCEECCCCCCCCCCC	46.41	28066266
662	Phosphorylation	SSGGAGASDDEDSAE CCCCCCCCCCCCCCC	44.68	26643407
667	Phosphorylation	GASDDEDSAEGQVQC CCCCCCCCCCCCEEE	26.60	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDTC1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDTC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDTC1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WDTC1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-511, AND MASSSPECTROMETRY.
PubMed: 19367708