dbPTM

WDR91_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WDR91_MOUSE
UniProt AC	Q7TMQ7
Protein Name	WD repeat-containing protein 91 {ECO:0000312\|MGI:MGI:2141558}
Gene Name	Wdr91 {ECO:0000312\|MGI:MGI:2141558}
Organism	Mus musculus (Mouse).
Sequence Length	748
Subcellular Localization	Early endosome membrane Peripheral membrane protein . Late endosome membrane .
Protein Description	Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (By similarity). May play a role in meiosis. [PubMed: 27346680]
Protein Sequence	MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDKIVDQLQQLMQVYDLAALRDYWSYLERRLFSRLEDIYRPTINKLKTSLFRFYLVYTIQTNRNDKAQEFFAKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIISLHNFLSVLFQCMPVPVILNFDAECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQQEEEAAALVQHKLPPYVSSMDRLGDSELALVCSQRPASLSQSPRVGFLSSLLPQSKKSPSRLSPAQGPPQAQSSAKKDSFSSQATKGKDSVPGAKDGKSLLSGPVPGEASWTHQRQRRLQDHGKERRELLSTSSSQSQCAERKPEVSGAEAEPCLELHMGPVEVLARVSTAGSEGDRPEQPFIVLSQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSISKSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDDMPRILSLACSPNGASFVCSAAAPSLTSQTDSSAPDIGSKGMNQVPGKLLLWDTKTMKQQLQFSLDPEPIAINCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCDENAVYSIGEDRKFIQWNIHKSGLKVSESNLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYMLTCSATGGLIYKLGSEEKVLENCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKLTTLLAHKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Phosphorylation	YLERRLFSRLEDIYR HHHHHHHHHHHHHHH	40.31	23970565
90	Phosphorylation	TINKLKTSLFRFYLV HHHHHHHHHHHEEEE	24.75	24719451
241	Phosphorylation	SMDRLGDSELALVCS CCCCCCCCHHHHHCC	32.48	25619855
248	Phosphorylation	SELALVCSQRPASLS CHHHHHCCCCCCCCC	23.03	25619855
253	Phosphorylation	VCSQRPASLSQSPRV HCCCCCCCCCCCCCC	31.10	22942356
255	Phosphorylation	SQRPASLSQSPRVGF CCCCCCCCCCCCCCH	26.56	21082442
257	Phosphorylation	RPASLSQSPRVGFLS CCCCCCCCCCCCHHH	15.99	25521595
270	Phosphorylation	LSSLLPQSKKSPSRL HHHHCCCCCCCCCCC	39.86	27180971
273	Phosphorylation	LLPQSKKSPSRLSPA HCCCCCCCCCCCCCC	31.66	29895711
275	Phosphorylation	PQSKKSPSRLSPAQG CCCCCCCCCCCCCCC	53.60	26643407
278	Phosphorylation	KKSPSRLSPAQGPPQ CCCCCCCCCCCCCCC	19.65	26643407
288	Phosphorylation	QGPPQAQSSAKKDSF CCCCCHHCCCCCCCC	34.97	30635358
289	Phosphorylation	GPPQAQSSAKKDSFS CCCCHHCCCCCCCCC	31.84	29109428
294	Phosphorylation	QSSAKKDSFSSQATK HCCCCCCCCCCCCCC	35.59	26824392
296	Phosphorylation	SAKKDSFSSQATKGK CCCCCCCCCCCCCCC	26.03	26160508
297	Phosphorylation	AKKDSFSSQATKGKD CCCCCCCCCCCCCCC	23.09	26160508
300	Phosphorylation	DSFSSQATKGKDSVP CCCCCCCCCCCCCCC	32.46	26160508
348	Phosphorylation	RRELLSTSSSQSQCA HHHHHHCCCCHHHHH	25.31	25338131
350	Phosphorylation	ELLSTSSSQSQCAER HHHHCCCCHHHHHHC	33.35	29899451
352	Phosphorylation	LSTSSSQSQCAERKP HHCCCCHHHHHHCCC	29.22	25521595
462	Acetylation	LSLEWATKRDRLLLL CCCHHCCCCCEEEEE	44.55	23236377

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of WDR91_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WDR91_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WDR91_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of WDR91_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WDR91_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-257, AND MASSSPECTROMETRY.	17242355 [Abstract]