WDR27_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDR27_HUMAN
• UniProt AC: A2RRH5
• Protein Name: WD repeat-containing protein 27
• Gene Name: WDR27
• Organism: Homo sapiens (Human).
• Sequence Length: 827
• Protein Sequence: MENPQDIFSSNGGCLSDIVIEKYLVESKESVSHVQLACSMQDCAFPLDGTELCIWNTKDPSHQLLILRGHHQPITAMAFGNKVNPLLICSASLDYVIMWNLDECREKVLQGLVPRGTVMGSLLGKVLCLQLSLDDHVVAVCAGNKIFMLDIETQAVRAELQGHLGPVTAVEFCPWRAGTLISASEDRGFKVWDHCTGSLIYSSSVLSAYPLLSLFIDAESRQLVTGCADGQLWIFSLMDGHHYRRVARVDLRKKTETFSTRRVKSGLCSQPEESQLPSTSALGKGEQVEVTFPVLRLAPCDLSLIPNSACGCLSSENTRCVWIGSSVGLFVFNLANLEVEAALYYKDFQSLSILLAGSCALRNRTADQKVLCLLASLFGGKIAVLEINPAALVRAQQCPSMGQSLSVPASSCVLPTSPLYLGIAKEKSTKAASEQRRAARNVMKDQRLVFHSKVRSSGYASAPHVTMFSPKTNIKSEGKGSSRSRSSCAREAYPVECAVPTKPGPQVAAAPTCTRVCCIQYSGDGQWLACGLANHLLLVFDASLTGTPAVFSGHDGAVNAVCWSQDRRWLLSAARDGTLRMWSARGAELALLLGKDMFSKPIQSAQFYYIDAFILLSSGPEFQLLRYHIDTCKDEIKRYKQKSKSKLICRLSTTGAVDMTSLSAVNDFYSHIVLAAGRNRTVEVFDLNAGCSAAVIAEAHSRPVHQICQNKGSSFTTQQPQAYNLFLTTAIGDGMRLWDLRTLRCERHFEGHPTRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQLATATLDGKLQLFLAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
125	Acetylation	VMGSLLGKVLCLQLS HHHHHHHHHHHHHCC	31.81	19816607
201	Phosphorylation	HCTGSLIYSSSVLSA CCCCCHHHCHHHHHH	14.06	-
265	Phosphorylation	FSTRRVKSGLCSQPE CCCCCCCCCCCCCCH	33.85	28509920
269	Phosphorylation	RVKSGLCSQPEESQL CCCCCCCCCCHHHCC	54.54	28509920
274	Phosphorylation	LCSQPEESQLPSTSA CCCCCHHHCCCCCCC	35.04	28509920
376	Phosphorylation	KVLCLLASLFGGKIA HHHHHHHHHHCCEEE	24.97	-
469	Phosphorylation	APHVTMFSPKTNIKS CCEEEEECCCCCCCC	18.05	24719451
599	Phosphorylation	LLGKDMFSKPIQSAQ HHCCCCCCCCCCCCC	30.77	25219547
669	Phosphorylation	LSAVNDFYSHIVLAA HHHHHHHHHHHHHCC	11.38	23879269
670	Phosphorylation	SAVNDFYSHIVLAAG HHHHHHHHHHHHCCC	13.51	23879269
757	Phosphorylation	EGHPTRGYPCGIAFS CCCCCCCCCCEEEEC	7.64	19702290
782	Phosphorylation	EDRHAYVYEMGSSTF CCCCEEEEEECCCCC	6.37	30576142
786	Phosphorylation	AYVYEMGSSTFSHRL EEEEEECCCCCCCCC	25.54	30576142
787	Phosphorylation	YVYEMGSSTFSHRLA EEEEECCCCCCCCCC	27.95	30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDR27_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDR27_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDR27_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of WDR27_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.