WDR24_MOUSE - dbPTM
WDR24_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WDR24_MOUSE
UniProt AC Q8CFJ9
Protein Name GATOR complex protein WDR24 {ECO:0000305}
Gene Name Wdr24 {ECO:0000312|MGI:MGI:2446285}
Organism Mus musculus (Mouse).
Sequence Length 790
Subcellular Localization Lysosome membrane .
Protein Description As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux..
Protein Sequence MEKMSRVSTALSGSALTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLNLRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQLFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSESVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTTHRAKEIHCVQTIASVARVKWRPECRHHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDSTLCQHLFRDASQPVERANPEGLCYGLFGDLAFAVKESLVAAESGRKPYAGDRRHPIFFKRKLDPAEPFSGLASSALSVFETESSGGSMSWFVDTAERYVLAGRPLAELCDHNAKVARELGRNQVAQTWTMLRIIYCSPGLVSSANLNHSVGKGSSCGLPLMNSFNLKDMGPGLGSETRLDRSKGDTRSDAALLDSSATLVTNEDNEETEGSDVPADYLLGDVEGEDDELYPLDTEHVHSEEPEYVLPQEAFPLRHEIVDTPSGPEHLQDKADSPHVSGNEADTASLAPVDSSSSLLSVSHALYDSRLPPDFFSVLVRDMLRFYAEQGDVQMAVSVLIVLGERVRKDIDEQTQEHWYTSYIDLLQRFCLWNVSNEVVKLSTSRAVSCLNQASTTLHVNCSHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSHGGHLQHIMKWLEGSSHCPAGCGHLCEYS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MEKMSRVSTALS
---CCCCCHHHHHHC		40.37-
8PhosphorylationMEKMSRVSTALSGSA
CCCCCHHHHHHCCCC		13.57-
12PhosphorylationSRVSTALSGSALTGR
CHHHHHHCCCCCCCC		28.3929514104
47PhosphorylationQVVVAGRSIFKIYAI
HHEEECCCEEEEEEE		31.3124719451
157PhosphorylationLRRKDSVSTFSGQSE
ECCCCCCCCCCCCCC		27.9022871156
176PhosphorylationVQFSIRDYFTFASTF
EEEEHHHCEEEEEEE		8.4830635358
178PhosphorylationFSIRDYFTFASTFEN
EEHHHCEEEEEEECC		16.4430635358
181PhosphorylationRDYFTFASTFENGNV
HHCEEEEEEECCCCE		29.4530635358
182PhosphorylationDYFTFASTFENGNVQ
HCEEEEEEECCCCEE		31.3830635358
253PhosphorylationHCVQTIASVARVKWR
HHHHHHHHHHCCCCC		16.6824719451
463PhosphorylationYCSPGLVSSANLNHS
EECCCHHHCCCCCCC		28.8623984901
464PhosphorylationCSPGLVSSANLNHSV
ECCCHHHCCCCCCCC		17.4423984901
470PhosphorylationSSANLNHSVGKGSSC
HCCCCCCCCCCCCCC		31.3426745281
484PhosphorylationCGLPLMNSFNLKDMG
CCCCCCCCCCHHHCC		11.1026745281
496PhosphorylationDMGPGLGSETRLDRS
HCCCCCCCCCCCCCC		40.6230352176
581PhosphorylationLRHEIVDTPSGPEHL
CCCEEECCCCCHHHH		14.4128066266
583PhosphorylationHEIVDTPSGPEHLQD
CEEECCCCCHHHHHC		69.9029472430
594PhosphorylationHLQDKADSPHVSGNE
HHHCCCCCCCCCCCC		23.0527087446
598PhosphorylationKADSPHVSGNEADTA
CCCCCCCCCCCCCCC		32.6327087446
604PhosphorylationVSGNEADTASLAPVD
CCCCCCCCCCCCCCC		25.7926160508
606PhosphorylationGNEADTASLAPVDSS
CCCCCCCCCCCCCCC		27.4426160508
612PhosphorylationASLAPVDSSSSLLSV
CCCCCCCCCCCHHHH		32.1429472430
613PhosphorylationSLAPVDSSSSLLSVS
CCCCCCCCCCHHHHH		21.3429472430
614PhosphorylationLAPVDSSSSLLSVSH
CCCCCCCCCHHHHHH		29.0229472430
615PhosphorylationAPVDSSSSLLSVSHA
CCCCCCCCHHHHHHH		34.9729472430
618PhosphorylationDSSSSLLSVSHALYD
CCCCCHHHHHHHHHH		27.2029472430
620PhosphorylationSSSLLSVSHALYDSR
CCCHHHHHHHHHHCC		10.3229472430
644PhosphorylationVRDMLRFYAEQGDVQ
HHHHHHHHHHCCCHH		11.6425159016
655PhosphorylationGDVQMAVSVLIVLGE
CCHHHHHEHHHHHCH		11.1525159016
727PhosphorylationSHCKRPMSSRGWVCD
HHCCCCCCCCCEECH		21.40-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of WDR24_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WDR24_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WDR24_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of WDR24_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WDR24_MOUSE

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory