WDFY4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WDFY4_HUMAN
• UniProt AC: Q6ZS81
• Protein Name: WD repeat- and FYVE domain-containing protein 4
• Gene Name: WDFY4
• Organism: Homo sapiens (Human).
• Sequence Length: 3184
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MEAEDLSKAEDRNEDPGSKNEGQLAAVQPDVPHGGQSSSPTALWDMLERKFLEYQQLTHKSPIERQKSLLSLLPLFLKAWEHSVGIICFPSLQRLAEDVSDQLAQQLQKALVGKPAEQARLAAGQLLWWKGDVDQDGYLLLKSVYVLTGTDSETLGRVAESGLPALLLQCLYLFFVFPLDKDELLESDLQVQKMFVQMLLNICSDSQGLEGLLSGSELQSLLIATTCLREHSCCFWKEPTFCVLRAISKAQNLSIIQYLQATDCVRLSLQNLSRLTDTLPAPEVSEAVSLILGFVKDSYPVSSALFLEFENSEGYPLLLKVLLRYDGLTQSEVDPHLEELLGLVVWLTTCGRSELKVFDSITYPQLEGFKFHHEASGVTVKNLQAFQVLQNVFHKASDSVLCIQVLSVIRTMWAWNARNFFLLEWTLQPISQFVEIMPLKPAPVQEHFFQLLEALVFELHYVPHEILRKVQHLIKESPGPSCTLMALQSILSIAGGDPLFTDIFRDSGLLGLLLAQLRKQAKIMRKSGNKVSTPGVQDPERELTCVMLRIVVTLLKGSVRNAVVLKDHGMVPFIKIFLDDECYREASLSILEQLSAINAEEYMSIIVGALCSSTQGELQLKLDLLKSLLRILVTPKGRAAFRVSSGFNGLLSLLSDLEGSLQEPPLQAWGAVSPRQTLELVLYTLCAVSAALHWDPVNGYFFRRNGLFEKLAEDLCLLGCFGALEEEGNLLRSWVDTKARPFADLLGTAFSSSGSLPPRIQSCLQILGFLDSMASGTLHLRGDLKESLRTKQGPVVDVQKGETGSDPQRNFKQWPDLEERMDEGDAAIMHPGVVCIMVRLLPRLYHEDHPQLSEEIQCSLASHIQSLVKSEKNRQVMCEAGLLGTLMASCHRALVTSGSPLHSRLIRIFEKLASQAIEPDVLRQFLGLGIPSSLSATTKILDSSHTHRGNPGCSGSQTAQGLAEGPWPAAPDAGLHPGVTQAPQPLGESQDSTTALQTALSLISMTSPRNLQPQRAALAPSFVEFDMSVEGYGCLFIPTLSTVMGTSTEYSVSGGIGTGATRPFPPPGGLTFSCWFLISRHGAATEGHPLRFLTLVRHLARTEQPFVCFSVSLCPDDLSLVVSTEEKEFQPLDVMEPEDDSEPSAGCQLQVRCGQLLACGQWHHLAVVVTKEMKRHCTVSTCLDGQVIGSAKMLYIQALPGPFLSMDPSAFVDVYGYIATPRVWKQKSSLIWRLGPTYLFEEAISMETLEVINKLGPRYCGNFQAVHVQGEDLDSEATPFVAEERVSFGLHIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIGAVAVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMCDFLMQHICGYQIMAFLLRKKASLLNHRIFQLILSVAGTVELGFRSSAITNTGVFQHILCNFELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKISTIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSGKTIWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLLYFLASPSLRTRFRDGLCAGSWVERSTEGVDIVMDNLKSQSPLPEQSPCLLPGFRVLNDFLAHHVHIPEVYLIVSTFFLQTPLTELMDGPKDSLDAMLQWLLQRHHQEEVLQAGLCTEGALLLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQDPAWRAPEFLQTLAIAAFPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGLQAPTKAHPARRKLREFTQLLLRELLLGASSPKQWLPLEVLLEASPDHATSQQKRDFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQPSAEAAAAPSLANISCFTQKLVEKLYSGMFSADPRHILLFILEHIMVVIETASSQRDTVLSTLYSSLNKVILYCLSKPQQSLSECLGLLSILGFLQEHWDVVFATYNSNISFLLCLMHCLLLLNERSYPEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQLVAQRQQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAWQHYLASEKKSLASRSNVAHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSEDFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGKPSKTSPAVTALAVSRNHTKLLVGDERGRIFCWSADG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	DVPHGGQSSSPTALW CCCCCCCCCCHHHHH	35.74	30108239
38	Phosphorylation	VPHGGQSSSPTALWD CCCCCCCCCHHHHHH	32.23	30108239
39	Phosphorylation	PHGGQSSSPTALWDM CCCCCCCCHHHHHHH	31.36	30108239
41	Phosphorylation	GGQSSSPTALWDMLE CCCCCCHHHHHHHHH	36.01	30108239
91	Phosphorylation	VGIICFPSLQRLAED CCEECCHHHHHHHHH	19.51	26091039
125	Ubiquitination	QARLAAGQLLWWKGD HHHHHHCCEEEECCC	28.76	21890473
240	Phosphorylation	CCFWKEPTFCVLRAI CCCCCCCCHHHHHHH	30.66	-
248	Phosphorylation	FCVLRAISKAQNLSI HHHHHHHHHHHCCCH	22.43	27174698
254	Phosphorylation	ISKAQNLSIIQYLQA HHHHHCCCHHHHHHH	25.79	27174698
258	Phosphorylation	QNLSIIQYLQATDCV HCCCHHHHHHHHCCH	7.14	27174698
262	Phosphorylation	IIQYLQATDCVRLSL HHHHHHHHCCHHHHH	19.57	27174698
320	Ubiquitination	EGYPLLLKVLLRYDG CCCCCHHHHHHHCCC	30.70	-
477	Phosphorylation	VQHLIKESPGPSCTL HHHHHHHCCCHHHHH	30.10	-
481	Phosphorylation	IKESPGPSCTLMALQ HHHCCCHHHHHHHHH	26.16	-
489	Phosphorylation	CTLMALQSILSIAGG HHHHHHHHHHHHHCC	26.75	-
507	Phosphorylation	FTDIFRDSGLLGLLL HHHHHHCCHHHHHHH	27.38	-
533	Phosphorylation	KSGNKVSTPGVQDPE HCCCCCCCCCCCCHH	27.35	30257219
627	Phosphorylation	LKLDLLKSLLRILVT HHHHHHHHHHHHHHC	32.38	24719451
634	Phosphorylation	SLLRILVTPKGRAAF HHHHHHHCCCCCHHH	18.81	23403867
673	Phosphorylation	LQAWGAVSPRQTLEL CCCCCCCCHHHHHHH	17.52	24719451
748	Phosphorylation	PFADLLGTAFSSSGS CHHHHHCHHHCCCCC	25.21	28111955
751	Phosphorylation	DLLGTAFSSSGSLPP HHHCHHHCCCCCCCH	22.56	28111955
752	Phosphorylation	LLGTAFSSSGSLPPR HHCHHHCCCCCCCHH	32.06	28111955
753	Phosphorylation	LGTAFSSSGSLPPRI HCHHHCCCCCCCHHH	31.07	28111955
755	Phosphorylation	TAFSSSGSLPPRIQS HHHCCCCCCCHHHHH	39.38	24719451
762	Phosphorylation	SLPPRIQSCLQILGF CCCHHHHHHHHHHHH	17.89	24043423
772	Phosphorylation	QILGFLDSMASGTLH HHHHHHHHHCCCEEE	20.56	24043423
775	Phosphorylation	GFLDSMASGTLHLRG HHHHHHCCCEEEECC	24.54	24043423
777	Phosphorylation	LDSMASGTLHLRGDL HHHHCCCEEEECCCH	14.44	24043423
885	Phosphorylation	CEAGLLGTLMASCHR HHHHHHHHHHHHHHH	17.21	24043423
889	Phosphorylation	LLGTLMASCHRALVT HHHHHHHHHHHHHHH	9.11	24043423
932	Phosphorylation	FLGLGIPSSLSATTK HHCCCCCCCCCCCCH	41.83	24043423
933	Phosphorylation	LGLGIPSSLSATTKI HCCCCCCCCCCCCHH	22.46	24043423
935	Phosphorylation	LGIPSSLSATTKILD CCCCCCCCCCCHHCC	26.05	24043423
937	Phosphorylation	IPSSLSATTKILDSS CCCCCCCCCHHCCCC	25.83	24043423
938	Phosphorylation	PSSLSATTKILDSSH CCCCCCCCHHCCCCC	18.79	24043423
1085	Phosphorylation	ISRHGAATEGHPLRF HHCCCCCCCCCHHHH	41.80	-
1174	Acetylation	VVVTKEMKRHCTVST EEEEHHHHHCCEEEE	39.83	18584305
1220	Phosphorylation	DVYGYIATPRVWKQK CCCCEECCHHHHHCC	11.32	24719451
1237	Phosphorylation	LIWRLGPTYLFEEAI HHHHHCCCHHHHCCC	30.93	-
1238	Phosphorylation	IWRLGPTYLFEEAIS HHHHCCCHHHHCCCC	16.72	-
1317	Ubiquitination	VDSRLIAKEMNISSR HHHHHHHHHCCCCCC	50.97	21890473
1317 (in isoform 1)	Ubiquitination	-	50.97	21890473
1317 (in isoform 4)	Ubiquitination	-	50.97	21890473
1317 (in isoform 5)	Ubiquitination	-	50.97	21890473
1346	Phosphorylation	HLSGSLRTIGAVAVG HHCCCCHHHCCEEEE	29.11	-
1357	Ubiquitination	VAVGQLGVRVFHSSP EEEECCEEEEEECCC	6.84	21890473
1400	Phosphorylation	AAVKVLHSVLTSNAM HHHHHHHHHHHHCHH	18.05	23401153
1403	Phosphorylation	KVLHSVLTSNAMCDF HHHHHHHHHCHHHHH	20.13	23401153
1404	Phosphorylation	VLHSVLTSNAMCDFL HHHHHHHHCHHHHHH	20.59	23401153
1418	Phosphorylation	LMQHICGYQIMAFLL HHHHHHHHHHHHHHH	7.17	23401153
1525	Phosphorylation	NEPSLIPSKISTIIG CCCCCCCHHHHHHHH	35.31	24719451
1649	Phosphorylation	LALKLLLYFLASPSL HHHHHHHHHHHCHHH	9.12	26270265
1653	Phosphorylation	LLLYFLASPSLRTRF HHHHHHHCHHHHHHC	19.71	26270265
1655	Phosphorylation	LYFLASPSLRTRFRD HHHHHCHHHHHHCCC	28.17	26270265
1686	Phosphorylation	IVMDNLKSQSPLPEQ CCCCCCCCCCCCCCC	38.77	30108239
1688	Phosphorylation	MDNLKSQSPLPEQSP CCCCCCCCCCCCCCC	35.18	30108239
1841	Phosphorylation	QKGVGAESTRNTSSP CCCCCCCCCCCCCCH	31.94	22468782
1842	Phosphorylation	KGVGAESTRNTSSPE CCCCCCCCCCCCCHH	21.31	22468782
1845	Phosphorylation	GAESTRNTSSPEAAA CCCCCCCCCCHHHHH	27.56	26657352
1846	Phosphorylation	AESTRNTSSPEAAAE CCCCCCCCCHHHHHC	47.66	28450419
1847	Phosphorylation	ESTRNTSSPEAAAEG CCCCCCCCHHHHHCC	25.40	28450419
1856	Phosphorylation	EAAAEGDSTVEGLQA HHHHCCCCCCCCCCC	45.25	22468782
1857	Phosphorylation	AAAEGDSTVEGLQAP HHHCCCCCCCCCCCC	27.58	30108239
1962	Phosphorylation	APSLANISCFTQKLV CCHHHHHHHHHHHHH	11.73	-
1998	Phosphorylation	HIMVVIETASSQRDT HHHHHHHHCCCCHHH	22.25	22210691
2005	Phosphorylation	TASSQRDTVLSTLYS HCCCCHHHHHHHHHH	26.07	22210691
2012	Phosphorylation	TVLSTLYSSLNKVIL HHHHHHHHHHHHHHH	31.31	22210691
2088	Phosphorylation	LEPKPRMSTYHQVFL CCCCCCCCCCEEEEC	27.39	23401153
2096	Phosphorylation	TYHQVFLSPNEDVKE CCEEEECCCCHHHHH	17.76	23401153
2146	Phosphorylation	DAFKIDLSVKPGERE HHHHCCCCCCCCCCE	25.09	27174698
2202	Phosphorylation	TLWSGSLSSAMKLMP EEECCCHHHHHHHCC	20.11	-
2230	Phosphorylation	FVSCIENYRRRGQEL HHHHHHHHHHHHHHH	7.84	-
2305	Phosphorylation	RKRIKRLSPLEALSS HHHHHHHCHHHHHHC	31.32	28450419
2311	Phosphorylation	LSPLEALSSGRHKES HCHHHHHHCCCCCCC	37.48	24719451
2312	Phosphorylation	SPLEALSSGRHKESQ CHHHHHHCCCCCCCC	40.47	30108239
2367	Phosphorylation	ALHESLHSEDFLELC HHHHHHCCHHHHHHH	44.12	28348404
2454	Phosphorylation	NLCSKDRSTDHYSCQ HHCCCCCCCCCCCCC	48.60	24043423
2455	Phosphorylation	LCSKDRSTDHYSCQC HCCCCCCCCCCCCCC	27.91	24043423
2458	Phosphorylation	KDRSTDHYSCQCHSY CCCCCCCCCCCCCCH	17.60	24043423
2459	Phosphorylation	DRSTDHYSCQCHSYA CCCCCCCCCCCCCHH	8.35	24043423
2464	Phosphorylation	HYSCQCHSYADMREL CCCCCCCCHHCHHHH	29.64	24043423
2465	Phosphorylation	YSCQCHSYADMRELR CCCCCCCHHCHHHHH	5.29	24043423
2508	Phosphorylation	DRSKAFKSFCSFQPS CCCHHHHHHHCCCHH	25.65	29396449
2511	Phosphorylation	KAFKSFCSFQPSLKG HHHHHHHCCCHHHCC	25.55	29396449
2521	Phosphorylation	PSLKGKATSEDTLSL HHHCCCCCCCCCCCC	35.81	26074081
2522	Phosphorylation	SLKGKATSEDTLSLR HHCCCCCCCCCCCCC	38.03	26074081
2525	Phosphorylation	GKATSEDTLSLRRYP CCCCCCCCCCCCCCC	17.75	26074081
2527	Phosphorylation	ATSEDTLSLRRYPGS CCCCCCCCCCCCCCC	23.17	26074081
2531	Phosphorylation	DTLSLRRYPGSDRIM CCCCCCCCCCCCCCC	12.91	26074081
2534	Phosphorylation	SLRRYPGSDRIMLQK CCCCCCCCCCCCEEC	21.15	26074081
2631	Phosphorylation	DMTVQCHYYTHYSSA CEEEEEEEEECCCHH	20.06	-
2686	Phosphorylation	SASRENMSDVRELTP HHCCCCHHHHHHHCH	44.53	-
2789	Phosphorylation	GDRMDLSSITDPLIK CCCCCHHHCCHHHHH	36.48	-
2791	Phosphorylation	RMDLSSITDPLIKST CCCHHHCCHHHHHHH	33.25	-
2804	Phosphorylation	STILGFVSNFGQVPK HHHHHHHHCCCCCCH	24.95	20562096
2815	Phosphorylation	QVPKQLFTKPHPART CCCHHHCCCCCCCCC	52.86	-
2882	Phosphorylation	GAIGHIVSTEKTILA CCCCCEECCCCEEEE	30.19	25690035
2883	Phosphorylation	AIGHIVSTEKTILAV CCCCEECCCCEEEEE	30.52	25690035
3107	Phosphorylation	KTEDVKMSVPGRPAG ECCEEEECCCCCCCC	21.31	23312004
3123	Phosphorylation	EPPAQPPSPRGHKWE CCCCCCCCCCCCCCH	33.63	23401153
3131	Ubiquitination	PRGHKWEKNLALSRE CCCCCCHHCHHHCEE	57.03	-
3136	Phosphorylation	WEKNLALSRELDVSI CHHCHHHCEEEEEEE	20.36	29496963
3142	Phosphorylation	LSRELDVSIALTGKP HCEEEEEEEEECCCC	11.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WDFY4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WDFY4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WDFY4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of WDFY4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.