WBP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WBP2_MOUSE
• UniProt AC: P97765
• Protein Name: WW domain-binding protein 2
• Gene Name: Wbp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 261
• Subcellular Localization: Cytoplasm . Nucleus . Translocates from cytoplasm to nucleus when phosphorylated.
• Protein Description: Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity (By similarity). Modulates expression of post-synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR. [PubMed: 26881968]
• Protein Sequence: MALNKNHSEGGGVIVNNTESILMSYDHVELTFNDMKNVPEAFKGTKKGTVYLTPYRVIFLSKGKDAMQSFMMPFYLMKDCEIKQPVFGANFIKGIVKAEAGGGWEGSASYKLTFTAGGAIEFGQRMLQVASQASRGEVPNGAYGYPYMPSGAYVFPPPVANGMYPCPPGYPYPPPPPEFYPGPPMMDGAMGYVQPPPPPYPGPMEPPVSGPSAPATPAAEAKAAEAAASAYYNPGNPHNVYMPTSQPPPPPYYPPEDKKTQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	O-linked_Glycosylation	VIVNNTESILMSYDH EEECCCCEEEEECCE	20.98	55414593
47	Malonylation	EAFKGTKKGTVYLTP HHHCCCCCCEEEECC	60.70	26320211
62	Acetylation	YRVIFLSKGKDAMQS EEEEEECCCHHHHHH	72.61	-
62	Acetylation	YRVIFLSKGKDAMQS EEEEEECCCHHHHHH	72.61	22826441
64	Ubiquitination	VIFLSKGKDAMQSFM EEEECCCHHHHHHCH	46.15	-
64	Ubiquitination	VIFLSKGKDAMQSFM EEEECCCHHHHHHCH	46.15	-
83	Ubiquitination	LMKDCEIKQPVFGAN HHCCCCCCCCCCCCC	26.68	-
83	Acetylation	LMKDCEIKQPVFGAN HHCCCCCCCCCCCCC	26.68	-
83	Ubiquitination	LMKDCEIKQPVFGAN HHCCCCCCCCCCCCC	26.68	-
83	Acetylation	LMKDCEIKQPVFGAN HHCCCCCCCCCCCCC	26.68	22826441
93	Acetylation	VFGANFIKGIVKAEA CCCCCCEEEEEEEEE	38.15	-
93	Acetylation	VFGANFIKGIVKAEA CCCCCCEEEEEEEEE	38.15	22826441
192	Phosphorylation	MMDGAMGYVQPPPPP CCCCCCCCCCCCCCC	5.26	-
231	Phosphorylation	AEAAASAYYNPGNPH HHHHHHHHCCCCCCC	10.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WBP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WBP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WBP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NEDD4_MOUSE	Nedd4	physical	11042109

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.