WASF3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WASF3_MOUSE
• UniProt AC: Q8VHI6
• Protein Name: Wiskott-Aldrich syndrome protein family member 3
• Gene Name: Wasf3
• Organism: Mus musculus (Mouse).
• Sequence Length: 501
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity)..
• Protein Sequence: MPLVKRNIEPRHLCRGALPEGVTSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTIQDQQVVSKNSIPNPVADIYNQSDKPPPLSILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKRVDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVHHGASSEGSLSPDTRSHTSDVTDYSYPATPNHALQAQPATPSYTAGDAPLHGTTNQGAEHEYRPSSASARHMALNRPQQPPPPPPPQAPEGSQASTSVAPADYGMLPAQIIEYYSPSGPPPPPPPPMIPSAQTAFVSPLQMPTQPPFPASAVSTYPTPPHQPSTGLLATAPPPPGPPPPPPGPPGPSSLSSSPMHGPPVAEAKRPEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSRRIAVEYSDSDDDSEFDENDWSD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Methylation	--MPLVKRNIEPRHL --CCCCCCCCCHHHH	41.71	16188383
39	Methylation	STLAAIIRQLSSLSK HHHHHHHHHHHHHHH	25.85	16188391
68	Phosphorylation	NFYIRANSLQDRIDR CEEEEHHHHHHHHHH	26.82	21659604
151	Phosphorylation	KKDGLKFYTDPSYFF CCCCCCCCCCHHHHH	14.51	-
162	Ubiquitination	SYFFDLWKEKMLQDT HHHHHHHHHHHCCCH	55.54	-
183	Acetylation	KRRQKEQKRVDGTTR HHHHHHHHHCCCCHH	56.32	15608227
193	Acetylation	DGTTREVKKVRKARN CCCHHHHHHHHHHHH	40.58	15608235
223	Phosphorylation	PDNRLSQSVHHGASS CCCCCCCCCCCCCCC	21.75	29899451
229	Phosphorylation	QSVHHGASSEGSLSP CCCCCCCCCCCCCCC	33.25	21183079
230	Phosphorylation	SVHHGASSEGSLSPD CCCCCCCCCCCCCCC	45.50	22817900
233	Phosphorylation	HGASSEGSLSPDTRS CCCCCCCCCCCCCCC	22.94	22817900
235	Phosphorylation	ASSEGSLSPDTRSHT CCCCCCCCCCCCCCC	23.56	22817900
248	Phosphorylation	HTSDVTDYSYPATPN CCCCCCCCCCCCCCC	10.76	-
337	Phosphorylation	LPAQIIEYYSPSGPP CCHHHHHHCCCCCCC	9.99	-
465	Ubiquitination	EQREQEAKREPVGND HHHHHHHHHCCCCHH	57.45	-
478	Phosphorylation	NDVATILSRRIAVEY HHHHHHHHCEEEEEE	18.70	-
485	Phosphorylation	SRRIAVEYSDSDDDS HCEEEEEECCCCCCC	15.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
151	Y	Phosphorylation	Kinase	ABL1	P00520	Uniprot
248	Y	Phosphorylation	Kinase	ABL1	P00520	Uniprot
337	Y	Phosphorylation	Kinase	ABL1	P00520	Uniprot
485	Y	Phosphorylation	Kinase	ABL1	P00520	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WASF3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WASF3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of WASF3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.