dbPTM

WASF1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WASF1_RAT
UniProt AC	Q5BJU7
Protein Name	Wiskott-Aldrich syndrome protein family member 1
Gene Name	Wasf1
Organism	Rattus norvegicus (Rat).
Sequence Length	559
Subcellular Localization	Cytoplasm, cytoskeleton . Cell junction, synapse . Cell junction, focal adhesion . Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas. Partial translocation to focal adhesion sites might be mediated by interactio
Protein Description	Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity)..
Protein Sequence	MPLVKRNIDPRHLCHTALPRGIKNELECVTNISLANIIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDITMRKAFRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNVLTPYRDDGKEGLKFYTNPSYFFDLWKEKMLQDTEDKRKEKRKQKQKNLDRPHEPEKVPRAPHDRRREWQKLAQGPELAEDDADLLHKHIEVANGPASHFETRPQTYVDHMDGSYSLSALPFSQMSELLSRAEERVLVRPHEPPPPPPMHAAGDARPTPTCVSSAAGLIENRPQSPAAGRTPVFVSPTPPPPPPPLPSALSTSSLRASMTSTPPPPVPPPPPPPAPALQAPAVPPPPAPLQIAPGVLHPAPPPIAPPLVQPSPPVARAAPVCETVPVHPLPQGEVQGLPPPPPPPPLPPPGIRPSSPVTVAALAHPPSGLHPTPSPAPGPHAPLMPPSPPSQVLPASEPKRHPSTLPVISDARSVLLEAIRKGIQLRKVEEQREQEAKHERIENDVATILSRRIAVEYSDSEDDSEFDEVDWLE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
265	Phosphorylation	SQMSELLSRAEERVL HHHHHHHHHHHHHHC	41.91	30181290
310	Phosphorylation	LIENRPQSPAAGRTP HHCCCCCCCCCCCCC	21.13	27097102
321	Phosphorylation	GRTPVFVSPTPPPPP CCCCEECCCCCCCCC	16.16	28432305
323	Phosphorylation	TPVFVSPTPPPPPPP CCEECCCCCCCCCCC	40.70	28432305
333	Phosphorylation	PPPPPLPSALSTSSL CCCCCCCCCCCCHHH	49.91	28432305
336	Phosphorylation	PPLPSALSTSSLRAS CCCCCCCCCHHHCCC	26.42	28432305
337	Phosphorylation	PLPSALSTSSLRASM CCCCCCCCHHHCCCC	24.16	28432305
338	Phosphorylation	LPSALSTSSLRASMT CCCCCCCHHHCCCCC	24.81	28432305
339	Phosphorylation	PSALSTSSLRASMTS CCCCCCHHHCCCCCC	23.20	28432305
341	Asymmetric dimethylarginine	ALSTSSLRASMTSTP CCCCHHHCCCCCCCC	26.94	-
341	Methylation	ALSTSSLRASMTSTP CCCCHHHCCCCCCCC	26.94	-
397	Phosphorylation	APPLVQPSPPVARAA CCCCCCCCCCCCCCC	25.41	19460862
441	Phosphorylation	PPGIRPSSPVTVAAL CCCCCCCCCCEEEEC	26.52	19460862
489	Phosphorylation	SEPKRHPSTLPVISD CCCCCCCCCCCHHCH	36.13	28432305
490	Phosphorylation	EPKRHPSTLPVISDA CCCCCCCCCCHHCHH	39.26	28432305
495	Phosphorylation	PSTLPVISDARSVLL CCCCCHHCHHHHHHH	26.00	28432305
523	Ubiquitination	EQREQEAKHERIEND HHHHHHHHHHHHHHH	45.29	-
533	Phosphorylation	RIENDVATILSRRIA HHHHHHHHHHHHHHE	23.46	28432305
536	Phosphorylation	NDVATILSRRIAVEY HHHHHHHHHHHEEEE	18.70	28432305
543	Phosphorylation	SRRIAVEYSDSEDDS HHHHEEEECCCCCCC	15.92	27097102
544	Phosphorylation	RRIAVEYSDSEDDSE HHHEEEECCCCCCCC	22.58	27097102
546	Phosphorylation	IAVEYSDSEDDSEFD HEEEECCCCCCCCCC	36.66	27097102
550	Phosphorylation	YSDSEDDSEFDEVDW ECCCCCCCCCCCCCC	53.11	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
310	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
397	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
441	S	Phosphorylation	Kinase	CDK5	Q00535	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WASF1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WASF1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WASF1_RAT

Related Literatures of Post-Translational Modification