| UniProt ID | VTDB_MOUSE | |
|---|---|---|
| UniProt AC | P21614 | |
| Protein Name | Vitamin D-binding protein | |
| Gene Name | Gc | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 476 | |
| Subcellular Localization | Secreted . | |
| Protein Description | Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.. | |
| Protein Sequence | MKRVLVLLLALAFGHALERGRDYEKDKVCNELAMLGKEDFRSLSLILYSRKFSSSTFEQVNQLVKEVVSLTEECCAEGADPTCYDTRTSELSVKSCESDAPFPVHPGTPECCTKEGLERKLCMAALSHQPQEFPTYVEPTNDEICEAFRRDPKGFADQFLYEYSSNYGQAPLPLLVAYTKNYLSMVGSCCTSANPTVCFVKERLQMKHLSLLTTMSNRVCSQYAAYGKEKSRLSHLIKLAQKVPTANLENVLPLAEDFTEILSRCCESTSEDCMASELPEHTIKICQNLSKKNSKFEECCQENTPMNIFMCTYFMPAAEPLQLPAIKLPTGKDLCGQSTTQAMDQYTFELSRRTQVPEVFLSKVLEPTLKTLRECCDTQDSVACFSTQSPLLKRQLTSFIEKGQEMCADYSENTFTEYKKKLAERLRTKTPNTSPAELKDMVEKHSDFASKCCSINSPPLYCSSQIDAEMIDTLQS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 95 | Phosphorylation | TSELSVKSCESDAPF CCEEEEECCCCCCCC | 22.44 | 24719451 | |
| 220 | S-palmitoylation | TTMSNRVCSQYAAYG HHHHHHHHHHHHHHC | 1.57 | 28526873 | |
| 234 | Phosphorylation | GKEKSRLSHLIKLAQ CCCHHHHHHHHHHHH | 18.35 | 23140645 | |
| 288 | N-linked_Glycosylation | HTIKICQNLSKKNSK HHHHHHHHHHHHCCC | 41.70 | 17330941 | |
| 363 | Ubiquitination | VPEVFLSKVLEPTLK CCHHHHHHHHHHHHH | 53.65 | 22790023 | |
| 398 | Phosphorylation | LLKRQLTSFIEKGQE HHHHHHHHHHHHHHH | 32.59 | 28059163 | |
| 410 | Nitration | GQEMCADYSENTFTE HHHHHHCCCCCCHHH | 10.20 | - | |
| 419 | Acetylation | ENTFTEYKKKLAERL CCCHHHHHHHHHHHH | 36.88 | 155669 | |
| 428 | Phosphorylation | KLAERLRTKTPNTSP HHHHHHHCCCCCCCH | 43.81 | - | |
| 430 | Phosphorylation | AERLRTKTPNTSPAE HHHHHCCCCCCCHHH | 22.59 | - | |
| 433 | Phosphorylation | LRTKTPNTSPAELKD HHCCCCCCCHHHHHH | 36.97 | - | |
| 434 | Phosphorylation | RTKTPNTSPAELKDM HCCCCCCCHHHHHHH | 28.84 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VTDB_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VTDB_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VTDB_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of VTDB_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."; Bernhard O.K., Kapp E.A., Simpson R.J.; J. Proteome Res. 6:987-995(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-288, AND MASSSPECTROMETRY. | |
