dbPTM

VTC4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VTC4_SCHPO
UniProt AC	P78810
Protein Name	Vacuolar transporter chaperone 4
Gene Name	vtc4
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	721
Subcellular Localization	Vacuole membrane Multi-pass membrane protein.
Protein Description	Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion..
Protein Sequence	MKFGQLLKETLMYEYKYSYVNYDKLKKEIKRRNDQGGWSEEDESDFVELLEKELDKVYSFQKNKSAEVMERIRFCEEQTDEVVRRLDSDNPPNENDFAILETELTDIMATVHDLAKFSELNYTAFYKIIKKHDKHTGWILKPVFAARLNAKPFFKEQYDLLVVKLSKLYDFVRTRGSPIKGDSAAGGTQQNFVRQTTKYWVHPNNVTELKIYILKHLPVLVFNPNKEFAREDAAITSIYYDNDDLDFYLGRLEKREGAEAIRLRWYGNMDNNNIFVERKTHREDWTGEKSVKARFPLKEKYVNAFLRGDYTVEEAFAKMRKDGKKSLKEIESLERLAKEVQYTVLSRGMKPYVRSFYERTAFQLPGDARVRISLDTNLSLIREDGPSRAGNNWRRMDIGIDYPFDQLPDEDIVRFPYAILEVKLQTQFGQDPPEWVNNLVNSHLVEAVPKFSKFIHGVSTLFYDRVTLLPYWFPQMDIDIRKPATHTFIQGRSQSGTHSSSVSANVLTDSENTPIHADGDNYVDEESRIGSSSTRNDNSTFQTSDSFQELDERTNLLDISKRKGRDSFVAALNSRLKDIKDSFFLETVPKFEEPTEPTVIYEQKYVSPPGKRIYVPVRVEPKTYFALERTYLDYLRYSILMGSIGITLFSFAKTRSGILGAASFTLVALFAIFYSTFLYLWRAVNIAKHNAVRYDDRFGPTAICVITFAAISANVILNFNA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
493	Phosphorylation	HTFIQGRSQSGTHSS EEEEECCCCCCCCCC	35.21	28889911
495	Phosphorylation	FIQGRSQSGTHSSSV EEECCCCCCCCCCCE	47.08	28889911
497	Phosphorylation	QGRSQSGTHSSSVSA ECCCCCCCCCCCEEE	24.67	28889911
501	Phosphorylation	QSGTHSSSVSANVLT CCCCCCCCEEEEECC	24.09	28889911
508	Phosphorylation	SVSANVLTDSENTPI CEEEEECCCCCCCCC	32.95	29996109
531	Phosphorylation	DEESRIGSSSTRNDN CCCCCCCCCCCCCCC	20.81	25720772
532	Phosphorylation	EESRIGSSSTRNDNS CCCCCCCCCCCCCCC	30.43	25720772
533	Phosphorylation	ESRIGSSSTRNDNST CCCCCCCCCCCCCCC	32.84	25720772
534	Phosphorylation	SRIGSSSTRNDNSTF CCCCCCCCCCCCCCC	35.12	28889911
539	Phosphorylation	SSTRNDNSTFQTSDS CCCCCCCCCCCCCCC	33.20	25720772
540	Phosphorylation	STRNDNSTFQTSDSF CCCCCCCCCCCCCCH	26.47	25720772
543	Phosphorylation	NDNSTFQTSDSFQEL CCCCCCCCCCCHHHH	30.25	25720772
544	Phosphorylation	DNSTFQTSDSFQELD CCCCCCCCCCHHHHH	22.07	25720772
546	Phosphorylation	STFQTSDSFQELDER CCCCCCCCHHHHHHH	28.70	28889911
567	Phosphorylation	SKRKGRDSFVAALNS HHHCCHHHHHHHHHH	21.91	28889911
574	Phosphorylation	SFVAALNSRLKDIKD HHHHHHHHHHHHHHH	39.58	21712547
582	Phosphorylation	RLKDIKDSFFLETVP HHHHHHHHHCCEECC	16.94	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VTC4_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VTC4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VTC4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of VTC4_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VTC4_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495; THR-497; SER-501;THR-534 AND SER-546, AND MASS SPECTROMETRY.	18257517 [Abstract]