VSI10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VSI10_HUMAN
• UniProt AC: Q8N0Z9
• Protein Name: V-set and immunoglobulin domain-containing protein 10
• Gene Name: VSIG10
• Organism: Homo sapiens (Human).
• Sequence Length: 540
• Subcellular Localization: Membrane ; Single-pass type I membrane protein .
• Protein Sequence: MAAGGSAPEPRVLVCLGALLAGWVAVGLEAVVIGEVHENVTLHCGNISGLRGQVTWYRNNSEPVFLLSSNSSLRPAEPRFSLVDATSLHIESLSLGDEGIYTCQEILNVTQWFQVWLQVASGPYQIEVHIVATGTLPNGTLYAARGSQVDFSCNSSSRPPPVVEWWFQALNSSSESFGHNLTVNFFSLLLISPNLQGNYTCLALNQLSKRHRKVTTELLVYYPPPSAPQCWAQMASGSFMLQLTCRWDGGYPDPDFLWIEEPGGVIVGKSKLGVEMLSESQLSDGKKFKCVTSHIVGPESGASCMVQIRGPSLLSEPMKTCFTGGNVTLTCQVSGAYPPAKILWLRNLTQPEVIIQPSSRHLITQDGQNSTLTIHNCSQDLDEGYYICRADSPVGVREMEIWLSVKEPLNIGGIVGTIVSLLLLGLAIISGLLLHYSPVFCWKVGNTSRGQNMDDVMVLVDSEEEEEEEEEEEEDAAVGEQEGAREREELPKEIPKQDHIHRVTALVNGNIEQMGNGFQDLQDDSSEEQSDIVQEEDRPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAAGGSAPEPRVL --CCCCCCCCCHHHH	39.47	-
36	Ubiquitination	EAVVIGEVHENVTLH EEEEEEECCCCEEEE	6.06	22817900
38	Ubiquitination	VVIGEVHENVTLHCG EEEEECCCCEEEECC	59.58	22817900
39	N-linked_Glycosylation	VIGEVHENVTLHCGN EEEECCCCEEEECCC	19.73	UniProtKB CARBOHYD
46	N-linked_Glycosylation	NVTLHCGNISGLRGQ CEEEECCCCCCCCCE	30.55	UniProtKB CARBOHYD
48	Phosphorylation	TLHCGNISGLRGQVT EEECCCCCCCCCEEE	35.46	24719451
53	Ubiquitination	NISGLRGQVTWYRNN CCCCCCCEEEEECCC	24.04	22817900
54	Ubiquitination	ISGLRGQVTWYRNNS CCCCCCEEEEECCCC	4.52	22817900
56	Ubiquitination	GLRGQVTWYRNNSEP CCCCEEEEECCCCCC	7.39	22817900
70	N-linked_Glycosylation	PVFLLSSNSSLRPAE CEEEECCCCCCCCCC	32.04	UniProtKB CARBOHYD
81	Phosphorylation	RPAEPRFSLVDATSL CCCCCCCEEECCCCC	28.85	26074081
86	Phosphorylation	RFSLVDATSLHIESL CCEEECCCCCEEEEC	27.62	26074081
87	Phosphorylation	FSLVDATSLHIESLS CEEECCCCCEEEECC	21.48	26074081
92	Phosphorylation	ATSLHIESLSLGDEG CCCCEEEECCCCCCC	23.74	26074081
94	Phosphorylation	SLHIESLSLGDEGIY CCEEEECCCCCCCEE	39.32	26074081
97	Ubiquitination	IESLSLGDEGIYTCQ EEECCCCCCCEEEHH	57.13	22817900
99	Ubiquitination	SLSLGDEGIYTCQEI ECCCCCCCEEEHHHH	23.96	22817900
101	Phosphorylation	SLGDEGIYTCQEILN CCCCCCEEEHHHHHC	16.60	26074081
108	N-linked_Glycosylation	YTCQEILNVTQWFQV EEHHHHHCCHHHHHH	40.21	UniProtKB CARBOHYD
114	Ubiquitination	LNVTQWFQVWLQVAS HCCHHHHHHHHHHHC	23.63	22817900
115	Ubiquitination	NVTQWFQVWLQVASG CCHHHHHHHHHHHCC	3.92	22817900
117	Ubiquitination	TQWFQVWLQVASGPY HHHHHHHHHHHCCCE	2.85	22817900
138	N-linked_Glycosylation	VATGTLPNGTLYAAR EEEEECCCCEEEEEC	60.23	UniProtKB CARBOHYD
168	Ubiquitination	PVVEWWFQALNSSSE CCHHHHHHHHHCCCC	31.08	22817900
170	Ubiquitination	VEWWFQALNSSSESF HHHHHHHHHCCCCCC	4.43	22817900
171	N-linked_Glycosylation	EWWFQALNSSSESFG HHHHHHHHCCCCCCC	42.75	UniProtKB CARBOHYD
180	N-linked_Glycosylation	SSESFGHNLTVNFFS CCCCCCCCEEEEEEE	37.47	UniProtKB CARBOHYD
185	Ubiquitination	GHNLTVNFFSLLLIS CCCEEEEEEEECCCC	3.70	22817900
186	Ubiquitination	HNLTVNFFSLLLISP CCEEEEEEEECCCCC	4.19	22817900
188	Ubiquitination	LTVNFFSLLLISPNL EEEEEEEECCCCCCC	3.69	22817900
198	N-linked_Glycosylation	ISPNLQGNYTCLALN CCCCCCCCEEHHHHH	18.91	UniProtKB CARBOHYD
269 (in isoform 1)	Ubiquitination	-	33.26	21906983
269	Ubiquitination	PGGVIVGKSKLGVEM CCEEEECCCHHHCEE	33.26	22817900
269 (in isoform 2)	Ubiquitination	-	33.26	21906983
271	Ubiquitination	GVIVGKSKLGVEMLS EEEECCCHHHCEECC	53.39	22817900
286 (in isoform 1)	Ubiquitination	-	61.09	21906983
286	Ubiquitination	ESQLSDGKKFKCVTS HHHCCCCCEEEEEEE	61.09	22817900
286 (in isoform 2)	Ubiquitination	-	61.09	21906983
287	Ubiquitination	SQLSDGKKFKCVTSH HHCCCCCEEEEEEEE	56.43	22817900
289	Ubiquitination	LSDGKKFKCVTSHIV CCCCCEEEEEEEEEE	36.35	22817900
292	Phosphorylation	GKKFKCVTSHIVGPE CCEEEEEEEEEECCC	24.86	18491316
293	Phosphorylation	KKFKCVTSHIVGPES CEEEEEEEEEECCCC	7.27	18491316
319	Acetylation	SLLSEPMKTCFTGGN HHCCCCCEECCCCCC	53.51	19807469
326	N-linked_Glycosylation	KTCFTGGNVTLTCQV EECCCCCCEEEEEEE	25.58	UniProtKB CARBOHYD
462 (in isoform 2)	Phosphorylation	-	39.15	26657352
462	Phosphorylation	DVMVLVDSEEEEEEE EEEEEECCHHHHHHH	39.15	26657352
496	Ubiquitination	ELPKEIPKQDHIHRV HCCCCCCCCCCCHHH	74.21	29967540
525	Phosphorylation	FQDLQDDSSEEQSDI CHHCCCCCHHHHHHH	48.19	28348404
526	Phosphorylation	QDLQDDSSEEQSDIV HHCCCCCHHHHHHHH	52.74	28348404
530	Phosphorylation	DDSSEEQSDIVQEED CCCHHHHHHHHCHHC	32.36	26471730

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VSI10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VSI10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VSI10_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of VSI10_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.