VPS52_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS52_RAT
• UniProt AC: O55166
• Protein Name: Vacuolar protein sorting-associated protein 52 homolog
• Gene Name: Vps52
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 723
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Recycling endosome . Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling end
• Protein Description: Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane..
• Protein Sequence: MAAAATMAAAARELVLRAGASDMEEEEGPLGAGSGLQEPLQLGELDITSDEFILDEVDVHIQANLEDELVKEALKTGVDLRHYSKQVELELQQIEQKSIRDYIQESENIASLHNQITACDAVLERMEQMLGAFQSDLSSISCEIRTLQEQSGAMNIRLRNRQAVRGKLGELVDGLVVPSALVTAILEAPVTEPRFLEQLQELDAKAAAVREQEARGTAACADVRGVLDRLRVKAVTKIREFILQKIYSFRKPMTNYQIPQTALLKYRFFYQFLLGNERATAKEVRDEYVETLSKIYLSYYRSYVGRLMKVQYEEVAEKDDLMGVEDTAKKGFFSKPSLRSRNTIFTLGTRGAVISPAELEAPILVPHTAQRGEQRYPFEALFRSQHYALLDNSCREYLFICEFFVVSGPAAHDLFHAVMGRTLSMTLKHLESYLADCYDAIAVFLCIHIVLRFRNIAAKRDVPALDRYWEQVLALLWPRFELILEMNVQSVRSTDPQRLGGLDTRPHYITRRYAEFSSALVSINQTIPNERTLQLLGQLQVEVENFVLRVAAEFSSRKEQLVFLINNYDMMLGVLMERAADDSKEVESFQQLLNARTQEFIEELLSPPFGGLVAFVKEAEALIERGQAERLRGEEARVTQLIRGFGSSWKASVESLSQDVMRSFTNFRNGTSIIQGALTQLIQLYHRFHRVLSQPQLRALPARAELINIHHLMVELKKHKPNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAATMAA ------CHHHHHHHH	13.05	-
251	Acetylation	QKIYSFRKPMTNYQI HHHHHCCCCCCCCCC	36.81	26302492
334	Phosphorylation	TAKKGFFSKPSLRSR HHHCCCCCCCCCCCC	41.20	23984901
337	Phosphorylation	KGFFSKPSLRSRNTI CCCCCCCCCCCCCEE	39.90	23984901
355	Phosphorylation	GTRGAVISPAELEAP CCCCEECCHHHHCCC	16.09	23984901
584	Ubiquitination	ERAADDSKEVESFQQ HHHCCCHHHHHHHHH	73.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS52_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS52_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS52_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of VPS52_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.