VPS45_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS45_RAT
• UniProt AC: O08700
• Protein Name: Vacuolar protein sorting-associated protein 45
• Gene Name: Vps45
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 570
• Subcellular Localization: Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Associated with Golgi/endosomal vesicles and the trans-Golgi network..
• Protein Description: May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network..
• Protein Sequence: MNVVFAVKQYISKMIEDSGPGMKVLLMDKETTGIVSMVYTQSEILQKEVYLFERIDSQNREIMKHLKAICFLRPTKENVDSLIQELRRPKYSIYFIYFSNVISKSDVKSLAEADEQEVVAEVQEFYGDYIAVNPHLFSLNILGCCQGRNWDPAQLSRTTQGLTALLLSLKKCPMIRYQLSSEAAKRLGECVKQVISKEYELFEFRRTEVPPLLLILDRCDDAITPLLNQWTYQAMVHELLGINNNRIDLSRVPGISKDLREVVLSAENDEFYANNMYLNFAEIGSNIKNLMEDFQKKRPKEQQKLESIADMKAFVENYPQFKKMSGTVSKHVTVVGELSRLVSERNLLEVSEVEQELACQNDHSSALQNVKRLLQNPKVTEFDAVRLVMLYALHYERHSSNSLPGLIVDLRSKGVAEKYRKLVSAVVEYGGKRVRGSDLFSPKDAVAITKQFLKGLKGVENVYTQHQPFLHETLDHLIKGKLKENLYPYLGPSTLRDRPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTIHNTKSFLEEVLASGLHSRSRESSQATSRSASRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
170	Acetylation	TALLLSLKKCPMIRY HHHHHHHCCCCCHHH	49.29	22902405
257	Ubiquitination	SRVPGISKDLREVVL HHCCCCCHHHHHHHH	59.88	-
307	Phosphorylation	KEQQKLESIADMKAF HHHHHHHHHHHHHHH	33.25	-
421	Acetylation	GVAEKYRKLVSAVVE CHHHHHHHHHHHHHH	50.58	22902405
441	Phosphorylation	VRGSDLFSPKDAVAI CCCCCCCCHHHHHHH	38.03	25403869
483	Acetylation	HLIKGKLKENLYPYL HHHHCCHHHCCCCCC	48.30	22902405
483	Ubiquitination	HLIKGKLKENLYPYL HHHHCCHHHCCCCCC	48.30	-
556	Phosphorylation	ASGLHSRSRESSQAT HCCCHHCCHHHHHCH	43.33	25403869
559	Phosphorylation	LHSRSRESSQATSRS CHHCCHHHHHCHHHH	27.00	25403869
560	Phosphorylation	HSRSRESSQATSRSA HHCCHHHHHCHHHHH	21.05	25403869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS45_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS45_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS45_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of VPS45_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.