VPS36_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VPS36_MOUSE
• UniProt AC: Q91XD6
• Protein Name: Vacuolar protein-sorting-associated protein 36
• Gene Name: Vps36
• Organism: Mus musculus (Mouse).
• Sequence Length: 386
• Subcellular Localization: Cytoplasm. Endosome. Late endosome . Membrane. Nucleus. Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
• Protein Description: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3..
• Protein Sequence: MDRFVWTSGLLEINETLVIQQRGVRVYDGEEKIKFDAGTLLLSTHRLIWRDQKNNECCMAIPLSQIVFIEEQAAGIGKSAKIVVHLHPAPSNKEPGPFQSSKNSYIRLSFKEHGQIEFYRRLSEEMTQRRWETVPVSQSLQTNKGPQPGRVRAVGIVGIERKLEEKRKETDKNISEAFEDLSKLMIKAKEMVELSKSIANKIKEKQGDVTEDETIRFKSYLLSMGIANPVTRETYGSGTQYHMQLAKQLAGILQAPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEALKLPIRLRVFDSGVMVIELQTHKEEEMVASALETVSERGSLTSEEFAKLVGMSVLLAKERLLLAEKMGHLCRDDSVEGLRFYPNLFMTQN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	QQRGVRVYDGEEKIK EECCEEEECCCCEEE	13.99	25367039
34	Acetylation	YDGEEKIKFDAGTLL ECCCCEEEECHHHHE	48.54	22826441
78	Ubiquitination	EQAAGIGKSAKIVVH HHHCCCCCCEEEEEE	45.37	-
109	Phosphorylation	KNSYIRLSFKEHGQI CCCEEEEEEECCCCH	25.15	26643407
144	Ubiquitination	SQSLQTNKGPQPGRV HHHHCCCCCCCCCCE	75.30	-
189	Ubiquitination	SKLMIKAKEMVELSK HHHHHHHHHHHHHHH	41.14	-
219	Phosphorylation	DETIRFKSYLLSMGI CCHHHHHHHHHHCCC	20.50	29472430
220	Phosphorylation	ETIRFKSYLLSMGIA CHHHHHHHHHHCCCC	16.56	29472430

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VPS36_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VPS36_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VPS36_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_MOUSE	Ubc	physical	17057714

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.