| UniProt ID | VPP1_RAT | |
|---|---|---|
| UniProt AC | P25286 | |
| Protein Name | V-type proton ATPase 116 kDa subunit a isoform 1 | |
| Gene Name | Atp6v0a1 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 838 | |
| Subcellular Localization |
Cytoplasmic vesicle membrane Multi-pass membrane protein. Melanosome. Coated vesicle. |
|
| Protein Description | Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).. | |
| Protein Sequence | MGELFRSEEMTLAQLFLQSEAAYCCVSELEELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLEESSSLLEPNEMGRGAPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTHGFQNIVDAYGIGTYREINPAPYTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSMVFSGRYIILLMGLFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTIGNWTEETLLGSSVLQLNPAIPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMSSLFGYLVILIFYKWTAYDAHSSRNAPSLLIHFINMFLFSYPESGNAMLYSGQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDAEEPTEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFFIFAAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYTGTGFKFLPFSFEHIREGKFDE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | Acetylation | DVNVFQRKFVNEVRR CCCHHHHHHHHHHHH | 42.77 | 24634199 | |
| 70 | Acetylation | RKLRFVEKEIRKANI HHHHHHHHHHHHCCC | 53.81 | 22902405 | |
| 74 | Ubiquitination | FVEKEIRKANIPIMD HHHHHHHHCCCCCCC | 51.99 | - | |
| 119 | Acetylation | NTNQEALKRNFLELT CCCHHHHHHHHHHHH | 52.95 | 22902405 | |
| 250 | Phosphorylation | SLYPCPETPQERKEM HHCCCCCCHHHHHHH | 18.53 | - | |
| 255 | Ubiquitination | PETPQERKEMASGVN CCCHHHHHHHHHCCC | 51.60 | - | |
| 288 | Ubiquitination | RVLQAAAKNIRVWFI HHHHHHHHHCCEEEE | 48.45 | - | |
| 360 | Phosphorylation | NRMQTNQTPPTYNKT HHHHCCCCCCCCCCC | 33.05 | - | |
| 363 | Phosphorylation | QTNQTPPTYNKTNKF HCCCCCCCCCCCCCC | 40.71 | - | |
| 364 | Phosphorylation | TNQTPPTYNKTNKFT CCCCCCCCCCCCCCC | 22.04 | - | |
| 366 | Ubiquitination | QTPPTYNKTNKFTHG CCCCCCCCCCCCCCC | 42.96 | - | |
| 369 | Acetylation | PTYNKTNKFTHGFQN CCCCCCCCCCCCHHH | 57.80 | 22902405 | |
| 667 | Ubiquitination | RHQYLRKKHLGTLNF HHHHHHHCCCCCEEC | 37.31 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPP1_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPP1_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPP1_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of VPP1_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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