VP26A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VP26A_RAT
• UniProt AC: Q6AY86
• Protein Name: Vacuolar protein sorting-associated protein 26A
• Gene Name: Vps26a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 327
• Subcellular Localization: Cytoplasm . Endosome membrane ; Peripheral membrane protein . Early endosome . Localizes to tubular profiles adjacent to endosomes. Predominantly found in early not late endosomes.
• Protein Description: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC complex seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required for retrograde transport of lysosomal enzyme receptor IGF2R. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Required for the endosomal localization of WASHC2 (indicative for the WASH complex). Required for the endosomal localization of TBC1D5. Mediates retromer cargo recognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP. Involved in retromer-independent lysosomal sorting of F2R. Involved in recycling of ADRB2. Acts redundantly with VSP26B in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1. Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins (By similarity)..
• Protein Sequence: MSFLGGFFGPICEIDVALSDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPEVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQASAEQPEM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFLGGFFG ------CCCCCCCCC	29.22	27097102
35	Acetylation	EMKTEDGKVEKHYLF EEECCCCCEEEEEEE	60.59	22902405
47	Phosphorylation	YLFYDGESVSGKVNL EEEECCCCCCCEEEE	27.41	23984901
49	Phosphorylation	FYDGESVSGKVNLAF EECCCCCCCEEEEEE	42.02	30181290
242	Ubiquitination	IMDGAPVKGESIPIR EECCCCCCCCCCCEE	56.77	-
315	Phosphorylation	NFHQRFESPESQASA CHHHHHCCHHHHHHH	31.12	27097102
318	Phosphorylation	QRFESPESQASAEQP HHHCCHHHHHHHCCC	34.14	27097102
321	Phosphorylation	ESPESQASAEQPEM- CCHHHHHHHCCCCC-	25.38	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VP26A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VP26A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VP26A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of VP26A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.