dbPTM

VIT6_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VIT6_CAEEL
UniProt AC	P18948
Protein Name	Vitellogenin-6
Gene Name	vit-6
Organism	Caenorhabditis elegans.
Sequence Length	1651
Subcellular Localization	Secreted.
Protein Description	Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). May play a role in cholesterol uptake. May be involved in thermotolerance. [PubMed: 24957743]
Protein Sequence	MKFFIALALLGAALASTHLDRYNSIERNIQESSFRAGREYRYLFNGQLSAGLPVPSTPQGISRLQSQVTLQWTDGNTVRMQLQKTRFATSQQESNSMKMLPFERFEEVERMNREHQELLSMPVEFDYEHGLVREIRFAENDQPWSENIKRAVINMLQVNILKKEKYEGAEKSDNQEPTFSFTNVERTLEGECEVLYTVEEIKKEDEQRWAKSINFDKCTRRPYIHHVQTPVCKDCQQTLEQDKMSSTVLNYNITGTSSSFLINSVELRSQHLFAPISEKHQLVSAFTLNTMELIYAGEKKTEIKQVRNEKTSELVYNQESEWAEQQWAQTGEEKYLRQLPQWTENKVEMIKKMFSLMAKQIEQGEAELEAAHTVARIVKVLRECNEEQLEQIYRHVAEHKDEKIAEQLRSIYFNTLALAGTRVTIQQFVDKVQSRKNIAPLKASVAIKTLVDMRYPSLAIAEDIARLCESDVSSSFPALRQSCWLTYGAIVNGVCGQTPRVFVQKNGVKMCPRDAKQRIVDKLVQQFESASTRYEKVLALKTLANAGLDLSVYPLEKIILNEQHETTIRTQAIESFRRLRTQMPTKIQRVLMPVYLNRQQPQHIRMSALHQIIYTQPEWSVLSQIGNQLRQERNQQVRAFTLSLLRSYANNESPCEQTFSSRVQSLLNNIPFSSQEIDRFESVYGKWSTYSRRHQSGFEANFASLFTTESVLPTEMMASIEGVLSGEWNQYFAQIGFTQKNMEKIIKKLLSNVQEKGLEQIVVRGKRASGSFQPTEFLSNLLEKLRITRRQSSEQDPHAFVYIRHRDMDYAFLPIDADSIPEVVRSMIQGGRLEIGDIERVLAQGIHFSASNAAFLYETVRRVPTPMGLPVQFTSKMPTISSIRGQVTFELEPKNGKSFDGLRLRVQAGPRVASTHVLSLRVICPIAEVGTKFLHQAVLNTPVDTEIRMNWEDKVVIRAIYNTPSEEKRIAMIQSRPVTFTRTVAPDARQYPEPIEMTYMLPAHKQLSQSLDREYPQIRVQGTLNRPTSVRIPQWIVDSNVEVYYKPNVEQYEAIFELNLYNNYKMEKNYEKVYKKHNGRRYLEAEPEYDEEEHREQITKKFEWLQNEKVYQHVAKFEIKPEVVKMEVEAVCNNDFHFCKTQIRGEELKATIQYVYPQTPRTVEELKEQKYRQLVVMGEMNYGENTIHININGQQSQEQKKFVKQIEQAPEHETLLEASRLDQYQTVVEYEFEPKPAQYFARYWNMVQAYLRTQYPWTSRIETREEPSRKNMIRATINVEPRQRLTVNMTIETPMETTVLERVELPFRLPTAQIHYQPRNSRYEQKPVMEKIAHHASKQANCVVKSTKINTFDQVAYRNQFTPCYSVLAKDCGSEKSEPRFVVLMKKINEKKEWKNVKVVYGENEIEMYKTEEGLICRVNGEEIEYQPESEIEKKQYNIIWLNKNTLKFDSDDVTVQFDGVNARIHLSALYRNQQCGLCGHYDNEKETEFYDAENQENTIPKFAKSYLYKDSKCNYEREMFEKEENFQRIEKNQEEEKDQEMNYEESRREQDDEPTEQVAIVERQHEICFTQKPVLRCQNGKSQESKKQKVTSVYCLPSSNSWARRQMREIRREPLAQWPEHKLRNLRDQPQMEERTVRVAVDQKCDKFDY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	IERNIQESSFRAGRE HHHHHHHHHHHCCCE	20.57	30078680
33	Phosphorylation	ERNIQESSFRAGREY HHHHHHHHHHCCCEE	20.28	30078680
252	N-linked_Glycosylation	SSTVLNYNITGTSSS CCEEEEEEEECCCCC	25.03	15888633
653	Phosphorylation	RSYANNESPCEQTFS HHHCCCCCCCHHHHH	36.65	21082442
792	Phosphorylation	LRITRRQSSEQDPHA HCHHCCCCCCCCCCC	33.75	30078680
793	Phosphorylation	RITRRQSSEQDPHAF CHHCCCCCCCCCCCE	30.82	30078680
1082	Phosphorylation	KKHNGRRYLEAEPEY HHHCCCCCEECCCCC	13.92	30078680
1089	Phosphorylation	YLEAEPEYDEEEHRE CEECCCCCCHHHHHH	39.09	30078680
1159	Phosphorylation	IQYVYPQTPRTVEEL EEEECCCCCCCHHHH	15.38	30078680
1224	Phosphorylation	EASRLDQYQTVVEYE HHHCHHHCCEEEEEE	13.06	30078680
1288	N-linked_Glycosylation	PRQRLTVNMTIETPM CCCCEEEEEEEECCC	19.35	17761667
1499	Phosphorylation	DAENQENTIPKFAKS ECCCCCCCCHHHHHH	37.59	30078680
1544	Phosphorylation	EKDQEMNYEESRREQ HHHHHCCHHHHHHHC	21.55	30078680
1547	Phosphorylation	QEMNYEESRREQDDE HHCCHHHHHHHCCCC	25.38	30078680

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VIT6_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VIT6_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VIT6_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of VIT6_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VIT6_CAEEL

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Proteomics reveals N-linked glycoprotein diversity in Caenorhabditiselegans and suggests an atypical translocation mechanism for integralmembrane proteins."; Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,Taoka M., Takahashi N., Isobe T.; Mol. Cell. Proteomics 6:2100-2109(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1288, AND MASSSPECTROMETRY.	17761667 [Abstract]
"Identification of the hydrophobic glycoproteins of Caenorhabditiselegans."; Fan X., She Y.-M., Bagshaw R.D., Callahan J.W., Schachter H.,Mahuran D.J.; Glycobiology 15:952-964(2005). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-252 AND ASN-1288, AND MASSSPECTROMETRY.	15888633 [Abstract]