VINC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VINC_RAT
• UniProt AC: P85972
• Protein Name: Vinculin {ECO:0000250|UniProtKB:P18206}
• Gene Name: Vcl {ECO:0000250|UniProtKB:P18206}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1066
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, adherens junction . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Cell membrane, sarcolemma ; Peripheral membrane protein ; Cytoplasmic side . Recruitment to
• Protein Description: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion..
• Protein Sequence: MPVFHTRTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTEDQILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNTVKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVGKMSAEINEIIRVLQLTSWDEDAWASKDTEAMKRALASIDSKLNQAKGWLRDPNASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKMLGQMTDQVADLRARGQGASPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQNWLADPNGGPEGEEQIRGALAEARKIAELCDDPKERDDILRSLGEIAALTSKLGDLRRQGKGDSPEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRGLVAEGHRLANVMMGPYRQDLLAKCDRVDQLAAQLADLAARGEGESPQARALASQLQDSLKDLKTQMQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGRLGATAEKAAAVGAANKSTVEGIQASVKTARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEAIDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSEDPKFREAVKAASDELSKTISPMVMDAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLHDEARKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Acetylation	SNLVRVGKETVQTTE HHHHHCCCCCCCCCH	47.56	22902405
71	Acetylation	TTEDQILKRDMPPAF CCHHHHHHCCCCHHH	48.24	22902405
97	Phosphorylation	QAAQMLQSDPYSVPA HHHHHHHCCCCCCCH	36.27	24945867
100	Phosphorylation	QMLQSDPYSVPARDY HHHHCCCCCCCHHHE	27.56	24945867
101	Phosphorylation	MLQSDPYSVPARDYL HHHCCCCCCCHHHEE	27.32	24945867
107	Phosphorylation	YSVPARDYLIDGSRG CCCCHHHEEEECCCC	10.45	-
170	Acetylation	NLGPGMTKMAKMIDE CCCCCHHHHHHHHHH	28.15	22902405
173	Acetylation	PGMTKMAKMIDERQQ CCHHHHHHHHHHHHH	32.65	22902405
219	Ubiquitination	FVTTKNSKNQGIEEA EEECCCCCCCCHHHH	63.78	-
228	Acetylation	QGIEEALKNRNFTVG CCHHHHHHCCCCCCH	61.99	22902405
260	Phosphorylation	WDEDAWASKDTEAMK CCCCHHHCCCHHHHH	21.99	22673903
272	Phosphorylation	AMKRALASIDSKLNQ HHHHHHHHHHHHHHH	27.98	22108457
275	Phosphorylation	RALASIDSKLNQAKG HHHHHHHHHHHHCCC	37.05	22673903
276	Acetylation	ALASIDSKLNQAKGW HHHHHHHHHHHCCCC	47.94	22902405
290	Phosphorylation	WLRDPNASPGDAGEQ CCCCCCCCCCHHHHH	35.74	23712012
346	Phosphorylation	RARGQGASPVAMQKA HHCCCCCCHHHHHHH	27.08	23712012
357	Phosphorylation	MQKAQQVSQGLDVLT HHHHHHHHHCHHHHH	17.75	22673903
364	Phosphorylation	SQGLDVLTAKVENAA HHCHHHHHHHHHHHH	25.04	25575281
366	Acetylation	GLDVLTAKVENAARK CHHHHHHHHHHHHHH	44.86	22902405
434	Phosphorylation	ERDDILRSLGEIAAL HHHHHHHHHHHHHHH	36.96	29779826
442	Phosphorylation	LGEIAALTSKLGDLR HHHHHHHHHHHHHHH	21.06	28432305
443	Phosphorylation	GEIAALTSKLGDLRR HHHHHHHHHHHHHHH	27.08	28432305
444	Acetylation	EIAALTSKLGDLRRQ HHHHHHHHHHHHHHC	51.78	22902405
456	Phosphorylation	RRQGKGDSPEARALA HHCCCCCCHHHHHHH	33.05	29779826
496	Acetylation	AAVHLEGKIEQAQRW HHHHHCHHHHHHHHH	33.42	22902405
537	Phosphorylation	ANVMMGPYRQDLLAK HCHHCCHHHHHHHHH	18.38	-
566	Phosphorylation	AARGEGESPQARALA HHCCCCCCHHHHHHH	32.92	28826663
574	Phosphorylation	PQARALASQLQDSLK HHHHHHHHHHHHHHH	32.07	22673903
579	Phosphorylation	LASQLQDSLKDLKTQ HHHHHHHHHHHHHHH	25.10	22673903
596	Phosphorylation	EAMTQEVSDVFSDTT HHHHHHHHHHHCCCC	27.57	24945867
600	Phosphorylation	QEVSDVFSDTTTPIK HHHHHHHCCCCCCCH	33.62	24945867
602	Phosphorylation	VSDVFSDTTTPIKLL HHHHHCCCCCCCHHE	31.22	24945867
603	Phosphorylation	SDVFSDTTTPIKLLA HHHHCCCCCCCHHEH	35.25	24945867
604	Phosphorylation	DVFSDTTTPIKLLAV HHHCCCCCCCHHEHH	25.71	24945867
672	Phosphorylation	VKTARELTPQVISAA HHHHHHHCHHHHHHH	13.61	-
692	Phosphorylation	NPGNQAAYEHFETMK CCCCHHHHHHHHHHH	16.98	-
699	Acetylation	YEHFETMKNQWIDNV HHHHHHHHHHHHHHH	54.10	22902405
719	Phosphorylation	LVDEAIDTKSLLDAS CCCHHHCHHHHHHHC	19.20	22668510
721	Phosphorylation	DEAIDTKSLLDASEE CHHHCHHHHHHHCHH	35.94	23712012
726	Phosphorylation	TKSLLDASEEAIKKD HHHHHHHCHHHHHHH	35.32	25575281
732	Acetylation	ASEEAIKKDLDKCKV HCHHHHHHHHHHHCH	58.36	22902405
768	Acetylation	NRILLVAKREVENSE HHHEEEEEHHHCCCC	41.43	22902405
778	Acetylation	VENSEDPKFREAVKA HCCCCCHHHHHHHHH	70.18	22902405
784	Acetylation	PKFREAVKAASDELS HHHHHHHHHHHHHHH	45.33	22902405
787	Phosphorylation	REAVKAASDELSKTI HHHHHHHHHHHHHCC	36.16	22108457
791	Phosphorylation	KAASDELSKTISPMV HHHHHHHHHCCCHHH	26.21	25575281
793	Phosphorylation	ASDELSKTISPMVMD HHHHHHHCCCHHHHC	24.26	28432305
795	Phosphorylation	DELSKTISPMVMDAK HHHHHCCCHHHHCHH	16.51	29779826
802	Acetylation	SPMVMDAKAVAGNIS CHHHHCHHHHCCCCC	38.85	22902405
809	Phosphorylation	KAVAGNISDPGLQKS HHHCCCCCCCHHHHH	41.58	21738781
815	Acetylation	ISDPGLQKSFLDSGY CCCCHHHHHHHHHHH	48.49	22902405
816	Phosphorylation	SDPGLQKSFLDSGYR CCCHHHHHHHHHHHH	20.34	23984901
820	Phosphorylation	LQKSFLDSGYRILGA HHHHHHHHHHHHHHH	39.61	27097102
822	Phosphorylation	KSFLDSGYRILGAVA HHHHHHHHHHHHHHH	9.83	27097102
915	Acetylation	EARKWSSKGNDIIAA HHHHHHHCCHHHHHH	57.10	22902405
924	Acetylation	NDIIAAAKRMALLMA HHHHHHHHHHHHHHH	37.67	22902405
952	Acetylation	RALIQCAKDIAKASD HHHHHHHHHHHHCCH	58.24	22902405
956	Acetylation	QCAKDIAKASDEVTR HHHHHHHHCCHHHHH	49.08	22902405
966	Acetylation	DEVTRLAKEVAKQCT HHHHHHHHHHHHHCC	58.26	22902405
973	Phosphorylation	KEVAKQCTDKRIRTN HHHHHHCCCHHHHHH	41.90	22673903
1035	Acetylation	QNLMQSVKETVREAE HHHHHHHHHHHHHHH	53.57	22902405
1061	Succinylation	FTLRWVRKTPWYQ-- CEEEEHHCCCCCC--	49.69	26843850
1065	Phosphorylation	WVRKTPWYQ------ EHHCCCCCC------	12.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1065	Y	Phosphorylation	Kinase	SRC-TYPE TYR-KINASES	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VINC_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VINC_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of VINC_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.