VINC_CAEEL - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VINC_CAEEL
• UniProt AC: P19826
• Protein Name: Vinculin
• Gene Name: deb-1
• Organism: Caenorhabditis elegans.
• Sequence Length: 1010
• Subcellular Localization: Cytoplasm, cytoskeleton . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic face of adhesion plaques (By similarity). In myoepithelial sheath cells, colocalizes in dense body-like structur
• Protein Description: Involved in cell adhesion (By similarity). May be involved in the attachment of the actin-based microfilaments to the plasma membrane. [PubMed: 17326220 Involved in ovulation]
• Protein Sequence: MPVFHTKTIENILEPVAQQVSRLVILHEEANDGNAMPDLTGPVGMVSRAVGNLIQVGYDTCDHSDDRILQQDMPPALQRVEGSSKLLEESSYSLKHDPYSVPARKKLIDGARGILQGTSALLLCFDESEVRKIIRVCRKANDYVAVSEVIESMADLQQFVKDISPVLHDVTNDVNLRQQELTHQVHREILIRCMDSIKVIAPILICSMKTSIELGTPHPRQGHAEAIANRNFMSQRMTEEMNEIIRVLQLTTYDEDEWDADNVTVMRKALSAAKSLLTAALDWLADPHARSGAVGEKAIRRICEYADRISARALPEDAQSIKRSIFEITSFTDELCNLRNNGQPDRENLAAQTARRLKDLVGSQNSSGLMGDALQNAQRHGGANPAHTAAGRLEQALRWLDNPGLDDGGLGLQALRLLTADARKLADRLNPQDRNRLLGLCSDIDRLAAQLADLERRGLGNSPEAHQIRNQLKNALRDLGDFMRRVLTDRVVDDFADITTPLKQFVEAVHADPYDPNREQNFVDKSQRLTDHSQSMTTTARLVASCGPSKSKKTVEAILDTAEKVEQLTPQLVNAGRVRLHNPGSEQHFENIHKQYADALHRLRSHVDDAIDTGEFVRASETAMRRYTNHCEGAINGADAHGLVNNSSQIARLGNRVLMTAQNEADNSEEPSFVSRVRNAADQLHNAIPPMVNNAKQIAQNPHDQYAAQNWRGTNDHLLNSVRAVGDAITGVPMSNGRHSSYQESISRASPYNPPPPSSQVIRSVNASPPTAPIIHNKMIIREDIPAPPRPPPPVELSPPPRPPPPPEYDEEEETRAFWERYPLPQASHQPMLAAAHNLHNELKQWSSQENDIVAAAKRMAILMARLSQLVRGEGGTKKDLINCSKAIADSSEEVTRLAVQLARLCTDIKMRTALLQVSERIPTIATQLKVLSTVKATMLGSANVIGPYGQPVEGSEEDDEAMQQLVHNAQNLMQSVKDVVRAAEAASIKIRTNSGLRLRWLRKPMWSNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	DTCDHSDDRILQQDM CCCCCCCCHHHHCCC	42.40	28854356
66	Phosphorylation	DTCDHSDDRILQQDM CCCCCCCCHHHHCCC	42.40	28854356
70	Phosphorylation	HSDDRILQQDMPPAL CCCCHHHHCCCCHHH	34.55	27067626
70	Phosphorylation	HSDDRILQQDMPPAL CCCCHHHHCCCCHHH	34.55	27067626
92	Phosphorylation	KLLEESSYSLKHDPY HHHHHCCCCCCCCCC	27.57	27067626
99	Phosphorylation	YSLKHDPYSVPARKK CCCCCCCCCCCHHHH	28.49	27067626
164	Phosphorylation	QQFVKDISPVLHDVT HHHHHHHHHHHHHHC	21.06	28854356
320	Phosphorylation	ALPEDAQSIKRSIFE CCCHHHHHHHHHHHH	31.62	28854356
462	Phosphorylation	ERRGLGNSPEAHQIR HHCCCCCCHHHHHHH	23.48	19530675
499	Phosphorylation	VDDFADITTPLKQFV HHCHHCCCHHHHHHH	23.94	30078680
500	Phosphorylation	DDFADITTPLKQFVE HCHHCCCHHHHHHHH	27.27	28854356
535	Phosphorylation	RLTDHSQSMTTTARL HHCCCHHHHHHHHHH	22.55	28854356
605	Phosphorylation	DALHRLRSHVDDAID HHHHHHHHCCCHHCH	32.24	19530675
613	Phosphorylation	HVDDAIDTGEFVRAS CCCHHCHHCHHHHHH	32.28	19530675
672	Phosphorylation	ADNSEEPSFVSRVRN CCCCCCCCHHHHHHH	41.37	28854356
706	Phosphorylation	AQNPHDQYAAQNWRG HHCHHHHHHHHHCCC	15.23	27067626
735	Phosphorylation	AITGVPMSNGRHSSY HHCCCCCCCCCCCCH	30.02	21082442
740	Phosphorylation	PMSNGRHSSYQESIS CCCCCCCCCHHHHHH	29.40	21082442
741	Phosphorylation	MSNGRHSSYQESISR CCCCCCCCHHHHHHC	25.39	28854356
742	Phosphorylation	SNGRHSSYQESISRA CCCCCCCHHHHHHCC	21.22	27067626
750	Phosphorylation	QESISRASPYNPPPP HHHHHCCCCCCCCCC	27.14	28854356
752	Phosphorylation	SISRASPYNPPPPSS HHHCCCCCCCCCCCH	37.49	19060867
764	Phosphorylation	PSSQVIRSVNASPPT CCHHHHHHCCCCCCC	14.48	21082442
768	Phosphorylation	VIRSVNASPPTAPII HHHHCCCCCCCCCEE	26.63	28854356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VINC_CAEEL !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VINC_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VINC_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.