VHAA3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VHAA3_ARATH
• UniProt AC: Q8W4S4
• Protein Name: V-type proton ATPase subunit a3
• Gene Name: VHA-a3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 821
• Subcellular Localization: Vacuole membrane ; Multi-pass membrane protein .
• Protein Description: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. Involved in vacuolar nutrient storage (e.g. accumulation and storage of nitrate) and in tolerance to some toxic ions (e.g. zinc ions sequestration in vacuoles)..
• Protein Sequence: MAESGGGGGCCPPMDLMRSETMQLVQLIVPMESAHLTVSYLGDLGLVQFKDLNSEKSPFQRTYAAQIKRCGEMARKIRFFRDQMSKAGVPAKEMQGKENDIDLDDVEVKLGELEAELVEINANNDKLQRSYNELMEYKLVLQKAGEFFSSAHRSAADQQRETESQQAGEDLLESPLLQEEKSIDSTKQVKLGFLTGLVPREKSMVFERILFRATRGNIFIRQTVIEEPVIDPNSGEKAEKNVFVVFYSGERAKSKILKICEAFGANRYPFSEDLGRQAQMITEVSGRLSELKTTIDAGLGQRNILLQTIGDKFELWNLKVRKEKAIYHTLNMLSLDVTKKCLVAEGWSPVFASREIQDALQRAAVDSNSQVGSIFQVLRTKESPPTYFRTNKFTSAIQEIVDAYGVAKYQEANPGVFTIVTFPFLFAVMFGDWGHGICILLATMYLILKEKKLASQKLGDIMEMAFGGRYVILMMSLFSIYTGLIYNEFFSIPFPLFAPSAYDCRDVSCSEATTIGLIKVRDTYPFGLDPVWHGSRSELPFLNSLKMKMSILLGVSQMNLGIIMSYFNARFFKSSVNIWFQFIPQMIFLNSLFGYLSVLIIIKWCTGSQADLYHVMIYMFLSPMDELGENQLFPHQKTLQLVLLFLALVSVPCMLLPKPFILKKQHEARHQGQAYAPLDETDESLHVETNGGGSHGHEEFEFSEIFVHQLIHTIEFVLGAVSNTASYLRLWALSLAHSELSSVFYEKVLLLAWGYNNPLILIVGVLVFIFATVGVLLVMETLSAFLHALRLHWVEFQNKFYEGDGYKFAPFTFIFTANEDE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAESGGGGG ------CCCCCCCCC		22223895
57	Phosphorylation	KDLNSEKSPFQRTYA ECCCCCCCCCHHHHH		30291188
162	Phosphorylation	AADQQRETESQQAGE HHHHHHHHHHHHHHH		26811356
164	Phosphorylation	DQQRETESQQAGEDL HHHHHHHHHHHHHHH		26811356
174	Phosphorylation	AGEDLLESPLLQEEK HHHHHHHCHHHCCHH		30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VHAA3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VHAA3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VHAA3_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of VHAA3_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.