VGLU2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VGLU2_RAT
• UniProt AC: Q9JI12
• Protein Name: Vesicular glutamate transporter 2
• Gene Name: Slc17a6
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 582
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Membrane ; Multi-pass membrane protein . Cell junction, synapse, synaptosome .
• Protein Description: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also play a role in the endocrine glutamatergic system of other tissues such as pineal gland and pancreas. May also mediate the transport of inorganic phosphate..
• Protein Sequence: MESVKQRILAPGKEGIKNFAGKSLGQIYRVLEKKQDNRETIELTEDGKPLEVPEKKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADPEETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATSQENGGWPNGWEKKEEFVQESAQDAYSYKDRDDYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	N-linked_Glycosylation	VAIVDMVNNSTIHRG EEEEECCCCCCCCCC	30.05	-
101	N-linked_Glycosylation	AIVDMVNNSTIHRGG EEEECCCCCCCCCCC	29.17	-
177	Phosphorylation	PSAARVHYGCVIFVR CCHHHHHCCHHHHHH	14.90	-
194	Phosphorylation	QGLVEGVTYPACHGI HHHHCCCCCHHHCCH	34.34	-
195	Phosphorylation	GLVEGVTYPACHGIW HHHCCCCCHHHCCHH	6.09	-
380	Phosphorylation	LRSKQILSTTTVRKI HHCCCCCCHHHHHHH	25.90	26022182
381	Phosphorylation	RSKQILSTTTVRKIM HCCCCCCHHHHHHHH	24.04	26022182
470	N-linked_Glycosylation	IVGAMTKNKSREEWQ HEEECCCCCCHHHHH	38.07	-
561	Ubiquitination	WPNGWEKKEEFVQES CCCCHHHHHHHHHHH	51.46	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VGLU2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VGLU2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VGLU2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of VGLU2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.