dbPTM

VGLL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VGLL3_HUMAN
UniProt AC	A8MV65
Protein Name	Transcription cofactor vestigial-like protein 3
Gene Name	VGLL3 {ECO:0000312\|Ensembl:ENSP00000381436}
Organism	Homo sapiens (Human).
Sequence Length	326
Subcellular Localization	Nucleus .
Protein Description	May act as a specific coactivator for the mammalian TEFs..
Protein Sequence	MSCAEVMYHPQPYGASQYLPNPMAATTCPTAYYQPAPQPGQQKKLAVFSKMQDSLEVTLPSKQEEEDEEEEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVVDEHFSRALGQAITLHPESAISKSKMGLTPLWRDSSALSSQRNSFPTSFWTSSYQPPPAPCLGGVHPDFQVTGPPGTFSAADPSPWPGHNLHQTGPAPPPAVSESWPYPLTSQVSPSYSHMHDVYMRHHHPHAHMHHRHRHHHHHHHPPAGSALDPSYGPLLMPSVHAARIPAPQCDITKTEPTTVTSATSAWAGAFHGTVDIVPSVGFDTGLQHQDKSKESPWY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Ubiquitination	PQPGQQKKLAVFSKM CCCCCHHHHHHHHCC	37.02	29967540
54	Phosphorylation	VFSKMQDSLEVTLPS HHHCCCCEEEEECCC	14.99	29507054
61	Phosphorylation	SLEVTLPSKQEEEDE EEEEECCCCCCHHHH	50.51	24719451
62	Sumoylation	LEVTLPSKQEEEDEE EEEECCCCCCHHHHH	60.84	28112733
115	Phosphorylation	RALGQAITLHPESAI HHHHHHHCCCHHHHH	23.25	-
124	Ubiquitination	HPESAISKSKMGLTP CHHHHHCHHHCCCCC	48.24	29967540
126	Acetylation	ESAISKSKMGLTPLW HHHHCHHHCCCCCCC	40.50	30593345
126	Sumoylation	ESAISKSKMGLTPLW HHHHCHHHCCCCCCC	40.50	-
126	Sumoylation	ESAISKSKMGLTPLW HHHHCHHHCCCCCCC	40.50	28112733
307	Phosphorylation	GTVDIVPSVGFDTGL CEEEECCCCCCCCCC	24.79	25332170

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VGLL3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VGLL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VGLL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of VGLL3_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VGLL3_HUMAN

Related Literatures of Post-Translational Modification