VGF_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VGF_RAT
• UniProt AC: P20156
• Protein Name: Neurosecretory protein VGF
• Gene Name: Vgf
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 617
• Subcellular Localization: Secreted . Cytoplasmic vesicle, secretory vesicle . Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
• Protein Description: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.; NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release. NERP-2 stimulates feeding behavior in an orexin-dependent manner.; TLQP-21 peptide plays a central and local role in the regulation of rat gastric motor functions..
• Protein Sequence: MKTFTLPASVLFCFLLLIRGLGAAPPGRSDVYPPPLGSEHNGQVAEDAVSRPKDDSVPEVRAARNSEPQDQGELFQGVDPRALAAVLLQALDRPASPPAVPAGSQQGTPEEAAEALLTESVRSQTHSLPASEIQASAVAPPRPQTQDNDPEADDRSEELEALASLLQELRDFSPSNAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPSVPSQFQARMSENVPLPETHQFGEGVSSPKTHLGETLTPLSKAYQSLSAPFPKVRRLEGSFLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRDLGGRGLQETQQERENEREEEAEQERRGGGEDEVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEEAPGHRRKDAEGTEEGGEEDDDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPARDELPDWNEVLPPWDREEDEVFPPGPYHPFPNYIRPRTLQPPASSRRRHFHHALPPARHHPDLEAQARRAQEEADAEERRLQEQEELENYIEHVLLHRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	GAAPPGRSDVYPPPL CCCCCCCCCCCCCCC	37.03	29779826
66	Phosphorylation	EVRAARNSEPQDQGE HHHHHCCCCCCCHHH	45.13	28432305
180	Pyrrolidone_carboxylic_acid	SPSNAKRQQETAAAE CHHHHHHHHHHHHHH	44.76	-
180	Pyrrolidone_carboxylic_acid	SPSNAKRQQETAAAE CHHHHHHHHHHHHHH	44.76	19164277
180	Pyrrolidone_carboxylic_acid	SPSNAKRQQETAAAE CHHHHHHHHHHHHHH	44.76	19164277
266	Phosphorylation	THLGETLTPLSKAYQ CCCCCCCCHHHHHHH	29.60	28551015
274	Phosphorylation	PLSKAYQSLSAPFPK HHHHHHHHCCCCCCC	16.18	28432305
276	Phosphorylation	SKAYQSLSAPFPKVR HHHHHHCCCCCCCCE	38.86	28432305
293	Phosphorylation	EGSFLGGSEAGERLL CCCCCCCCHHHHHHH	23.60	28432305
313	Pyrrolidone_carboxylic_acid	QVEAGRRQAEATRQA HHHHHHHHHHHHHHH	42.04	-
313	Pyrrolidone_carboxylic_acid	QVEAGRRQAEATRQA HHHHHHHHHHHHHHH	42.04	19194657
313	Pyrrolidone_carboxylic_acid	QVEAGRRQAEATRQA HHHHHHHHHHHHHHH	42.04	19194657
423	Phosphorylation	AGAEDKRSQEEAPGH CCCCCCCCCCCCCCC	47.92	30240740

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VGF_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VGF_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VGF_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of VGF_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.