VEGFD_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VEGFD_MOUSE
• UniProt AC: P97946
• Protein Name: Vascular endothelial growth factor D {ECO:0000312|MGI:MGI:108037}
• Gene Name: Vegfd {ECO:0000312|MGI:MGI:108037}
• Organism: Mus musculus (Mouse).
• Sequence Length: 358
• Subcellular Localization: Secreted.
• Protein Description: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-3 (Flt4) receptor..
• Protein Sequence: MYGEWGMGNILMMFHVYLVQGFRSEHGPVKDFSFERSSRSMLERSEQQIRAASSLEELLQIAHSEDWKLWRCRLKLKSLASMDSRSASHRSTRFAATFYDTETLKVIDEEWQRTQCSPRETCVEVASELGKTTNTFFKPPCVNVFRCGGCCNEEGVMCMNTSTSYISKQLFEISVPLTSVPELVPVKIANHTGCKCLPTGPRHPYSIIRRSIQTPEEDECPHSKKLCPIDMLWDNTKCKCVLQDETPLPGTEDHSYLQEPTLCGPHMTFDEDRCECVCKAPCPGDLIQHPENCSCFECKESLESCCQKHKIFHPDTCSCEDRCPFHTRTCASRKPACGKHWRFPKETRAQGLYSQENP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	KDFSFERSSRSMLER CCCCCCHHHHHHHHH	23.94	30635358
38	Phosphorylation	DFSFERSSRSMLERS CCCCCHHHHHHHHHH	34.30	30635358
40	Phosphorylation	SFERSSRSMLERSEQ CCCHHHHHHHHHHHH	29.66	30635358
54	Phosphorylation	QQIRAASSLEELLQI HHHHHHHCHHHHHHH	34.76	25338131
77	Ubiquitination	WRCRLKLKSLASMDS HHHHHHHHHHHHCCC	41.66	22790023
84	Phosphorylation	KSLASMDSRSASHRS HHHHHCCCCCCCHHH	21.35	21189417
160	N-linked_Glycosylation	EEGVMCMNTSTSYIS CCCCEECCCCCHHHH	26.42	-
190	N-linked_Glycosylation	LVPVKIANHTGCKCL CEEEEECCCCCCCCC	36.40	-
292	N-linked_Glycosylation	DLIQHPENCSCFECK CCCCCCCCCCCCCCH	27.70	-
354	Phosphorylation	TRAQGLYSQENP--- HHHCCCCCCCCC---	35.74	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VEGFD_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VEGFD_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VEGFD_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VEGFD_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.