VDR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VDR_MOUSE
• UniProt AC: P48281
• Protein Name: Vitamin D3 receptor
• Gene Name: Vdr
• Organism: Mus musculus (Mouse).
• Sequence Length: 422
• Subcellular Localization: Nucleus . Cytoplasm . Localizes mainly to the nucleus. Localization to the nucleus is enhanced by vitamin D3.
• Protein Description: Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis..
• Protein Sequence: MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMIMKRKEEEALKDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPIRADVSTGSYSPRPTLSFSGDSSSNSDLYTPSLDMMEPASFSTMDLNEEGSDDPSVTLDLSPLSMLPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTLDDMSWDCGSQDYKYDITDVSRAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGNEIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
69	Phosphorylation	FNGDCRITKDNRRHC CCCCEEECCCCHHHC	17.00	-
165	Phosphorylation	RADVSTGSYSPRPTL CCCCCCCCCCCCCEE	23.64	21189417
167	Phosphorylation	DVSTGSYSPRPTLSF CCCCCCCCCCCEEEE	19.01	21189417
250	Phosphorylation	IPGFRDLTSDDQIVL CCCCCCCCCCCEEEE	34.11	26370283
251	Phosphorylation	PGFRDLTSDDQIVLL CCCCCCCCCCEEEEE	46.62	26370283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VDR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VDR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VDR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOA1_MOUSE	Ncoa1	physical	15610065

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.