VDAC3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VDAC3_RAT
• UniProt AC: Q9R1Z0
• Protein Name: Voltage-dependent anion-selective channel protein 3
• Gene Name: Vdac3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 283
• Subcellular Localization: Mitochondrion outer membrane.
• Protein Description: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules..
• Protein Sequence: MCSTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLIFTQKWNTDNTLGTEISWENKLAEGLKLTVDTIFVPNTGKKSGKLKASYRRDCFSVGSKVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLCQNNFALGYKAEDFQLHTHVNDGTEFGGSIYQRVNEKIETSINLAWTAGSNNTRFGIAAKYRLDCRTSLSAKVNNASLIGLGYTQSLRPGVKLTLSALVDGKNFNAGGHKVGLGFELEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MCSTPTYCD ------CCCCCCCCC	6.62	-
3	Phosphorylation	-----MCSTPTYCDL -----CCCCCCCCCH	35.80	23984901
4	Phosphorylation	----MCSTPTYCDLG ----CCCCCCCCCHH	18.09	23984901
6	Phosphorylation	--MCSTPTYCDLGKA --CCCCCCCCCHHHH	36.55	27097102
7	Phosphorylation	-MCSTPTYCDLGKAA -CCCCCCCCCHHHHH	5.79	27097102
12	Acetylation	PTYCDLGKAAKDVFN CCCCCHHHHHHHHHH	53.09	22902405
15	Acetylation	CDLGKAAKDVFNKGY CCHHHHHHHHHHCCC	60.32	22902405
15	Ubiquitination	CDLGKAAKDVFNKGY CCHHHHHHHHHHCCC	60.32	-
20	Acetylation	AAKDVFNKGYGFGMV HHHHHHHCCCCCEEE	41.88	22902405
20	Ubiquitination	AAKDVFNKGYGFGMV HHHHHHHCCCCCEEE	41.88	-
20	Succinylation	AAKDVFNKGYGFGMV HHHHHHHCCCCCEEE	41.88	-
33	Phosphorylation	MVKIDLKTKSCSGVE EEEEEECCCCCCCCE	35.17	17478130
42	Phosphorylation	SCSGVEFSTSGHAYT CCCCCEEECCCEEEE	14.25	25575281
43	Phosphorylation	CSGVEFSTSGHAYTD CCCCEEECCCEEEEC	44.01	25575281
44	Phosphorylation	SGVEFSTSGHAYTDT CCCEEECCCEEEECC	27.64	25575281
48	Phosphorylation	FSTSGHAYTDTGKAS EECCCEEEECCCCCC	10.24	25575281
49	Phosphorylation	STSGHAYTDTGKASG ECCCEEEECCCCCCC	28.06	25575281
51	Phosphorylation	SGHAYTDTGKASGNL CCEEEECCCCCCCCC	32.55	25575281
55	Phosphorylation	YTDTGKASGNLETKY EECCCCCCCCCCCCE	31.53	23991683
61	Acetylation	ASGNLETKYKVCNYG CCCCCCCCEEEECEE	33.43	22902405
63	Acetylation	GNLETKYKVCNYGLI CCCCCCEEEECEEEE	41.70	25786129
67	Phosphorylation	TKYKVCNYGLIFTQK CCEEEECEEEEEEEE	14.26	-
74	Acetylation	YGLIFTQKWNTDNTL EEEEEEEECCCCCCC	39.08	26302492
90	Acetylation	TEISWENKLAEGLKL CEECEEHHHHCCCEE	37.24	22902405
96	Acetylation	NKLAEGLKLTVDTIF HHHHCCCEEEEEEEE	53.63	22902405
107	Phosphorylation	DTIFVPNTGKKSGKL EEEECCCCCCCCCCE	44.29	-
109	Ubiquitination	IFVPNTGKKSGKLKA EECCCCCCCCCCEEE	41.55	-
109	Acetylation	IFVPNTGKKSGKLKA EECCCCCCCCCCEEE	41.55	22902405
117	Phosphorylation	KSGKLKASYRRDCFS CCCCEEEEEECCCEE	20.00	23991683
118	Phosphorylation	SGKLKASYRRDCFSV CCCEEEEEECCCEEC	17.96	23991683
163	Acetylation	SFDTAKSKLCQNNFA CHHHHHHHHHCCCCC	53.20	25786129
174	Acetylation	NNFALGYKAEDFQLH CCCCCCEEEEEEEEE	43.43	25786129
224	Acetylation	TRFGIAAKYRLDCRT CEEEEEEEEEEECCC	23.14	22902405
236	Acetylation	CRTSLSAKVNNASLI CCCCEEEEECCEEEE	41.96	22902405
241	Phosphorylation	SAKVNNASLIGLGYT EEEECCEEEEECCCC	23.73	28432305
247	Phosphorylation	ASLIGLGYTQSLRPG EEEEECCCCCCCCCC	13.47	28432305
248	Phosphorylation	SLIGLGYTQSLRPGV EEEECCCCCCCCCCC	15.19	28432305
250	Phosphorylation	IGLGYTQSLRPGVKL EECCCCCCCCCCCEE	20.67	28432305
256	Acetylation	QSLRPGVKLTLSALV CCCCCCCEEEEEEEE	41.49	25786129
266	Acetylation	LSALVDGKNFNAGGH EEEEECCCCCCCCCC	54.63	22902405
274	Ubiquitination	NFNAGGHKVGLGFEL CCCCCCCEEECCEEE	41.07	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VDAC3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VDAC3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VDAC3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of VDAC3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Post-translational modifications of rat liver mitochondrial outermembrane proteins identified by mass spectrometry.";
Distler A.M., Kerner J., Hoppel C.L.;
Biochim. Biophys. Acta 1774:628-636(2007).
Cited for: PROTEIN SEQUENCE OF 29-34 AND 236-245, PHOSPHORYLATION AT THR-33 ANDSER-241, AND MASS SPECTROMETRY.
PubMed: 17478130