VDAC2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VDAC2_ARATH
• UniProt AC: Q9FJX3
• Protein Name: Mitochondrial outer membrane protein porin 2
• Gene Name: VDAC2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 276
• Subcellular Localization: Mitochondrion outer membrane . Also localized in other unidentified cellular compartments.
• Protein Description: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Involved in plant growth and development at the vegetative and reproductive stages. Is important for leaf and pollen development and mitochondrial membrane potential steady state. May be involved in ABA-mediated early seedling development and disease resistance..
• Protein Sequence: MSKGPGLFTDIGKKAKDLLTRDYNSDQKFSISTYSASGVALTSTALKKGGVHAADVATQYKYKNALFDVKIDTDSSVLTTVTLTEILPSTKAIASFKVPDYNSAKLEVQYFHDHATVTAAAALKQNPLIDITATLGSPVISFGAEAGYDTTSKTFTKYNAGISVTKPDACLSIILGDKGDSLKASYLHHFDEFKRTAAVGEVYRKFSTNENTITVGGLYAIDHSTAVKAKLNNHGTLGALLQHEVLPRSLVTVSSEIDTKALEKHPRFGLSLALKP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSKGPGLFT ------CCCCCCCCC	46.44	25561503
9	Phosphorylation	SKGPGLFTDIGKKAK CCCCCCCCCHHHHHH	31.58	25561503
13	Acetylation	GLFTDIGKKAKDLLT CCCCCHHHHHHHHHH	50.30	24727099
61	Acetylation	ADVATQYKYKNALFD HHHHHHCCCCCEEEE	39.67	24727099
76	Phosphorylation	VKIDTDSSVLTTVTL EEECCCCCCEEEEEE	24.77	-
236	Phosphorylation	AKLNNHGTLGALLQH HHHCCCCHHHHHHHC	17.92	21705391
260	Acetylation	VSSEIDTKALEKHPR ECCCCCHHHHHHCCC	47.42	24727099

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VDAC2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VDAC2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VDAC2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of VDAC2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.