VATE2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATE2_MOUSE
• UniProt AC: Q9D593
• Protein Name: V-type proton ATPase subunit E 2
• Gene Name: Atp6v1e2
• Organism: Mus musculus (Mouse).
• Sequence Length: 226
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome..
• Protein Sequence: MALTDIDVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMDYFEKKEKQIEQQKKIQLSTMRNQARITVLRARDNLILELLKDAKMRLSRIVSDEEIYQDLLDKLVLQALLRLLEPVMIVRCRPQDLHLVESAVLRAIPQYMRLCQKHLEVQVDQTEHLPSNAAGGVEVYSSDQKIKVSNTLESRLNLAAMQKMPEIRGILFGDNTSRKFFT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	Acetylation	EKQIEQQKKIQLSTM HHHHHHHHHHCHHHH	52.09	30985491
191	Ubiquitination	YSSDQKIKVSNTLES ECCCCEEEECCCHHH	46.80	-
195	Phosphorylation	QKIKVSNTLESRLNL CEEEECCCHHHHHHH	25.13	29899451
198	Phosphorylation	KVSNTLESRLNLAAM EECCCHHHHHHHHHH	45.22	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATE2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATE2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATE2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VATE2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.