VATE1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATE1_RAT
• UniProt AC: Q6PCU2
• Protein Name: V-type proton ATPase subunit E 1
• Gene Name: Atp6v1e1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 226
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRARDDLITDLLNEAKQRLSKVVKDTTRYQVLLDGLVLQGLYQLLEPRMIVRCRKQDFPLVKAAVQKAIPMYKIATKKDVDVQIDLEAYLPEDIAGGVEIYNGDRKIKVSNTLESRLDLIAQQMMPEVRGALFGANANRKFLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MALSDADVQ ------CCCCHHHHH	18.77	-
4	Phosphorylation	----MALSDADVQKQ ----CCCCHHHHHHH	22.63	23984901
10	Acetylation	LSDADVQKQIKHMMA CCHHHHHHHHHHHHH	54.56	22902405
52	Acetylation	LVQTQRLKIMEYYEK CHHHHHHHHHHHHHH	42.04	22902405
56	Phosphorylation	QRLKIMEYYEKKEKQ HHHHHHHHHHHHHHH	10.27	30181290
57	Phosphorylation	RLKIMEYYEKKEKQI HHHHHHHHHHHHHHH	14.15	30181290
59	Acetylation	KIMEYYEKKEKQIEQ HHHHHHHHHHHHHHH	50.54	22902405
60	Acetylation	IMEYYEKKEKQIEQQ HHHHHHHHHHHHHHH	59.20	22902405
99	Acetylation	TDLLNEAKQRLSKVV HHHHHHHHHHHHHHH	29.76	22902405
138	Ubiquitination	RMIVRCRKQDFPLVK CEEEEECCCCCHHHH	58.82	-
145	Acetylation	KQDFPLVKAAVQKAI CCCCHHHHHHHHHHC	38.01	22902405
150	Acetylation	LVKAAVQKAIPMYKI HHHHHHHHHCCHHEE	41.50	22902405
156	Acetylation	QKAIPMYKIATKKDV HHHCCHHEECCCCCC	21.44	22902405
191	Acetylation	YNGDRKIKVSNTLES ECCCCEEEECCCHHH	42.52	72592213

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATE1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATE1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATE1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of VATE1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.