| UniProt ID | VATB2_RAT | |
|---|---|---|
| UniProt AC | P62815 | |
| Protein Name | V-type proton ATPase subunit B, brain isoform | |
| Gene Name | Atp6v1b2 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 511 | |
| Subcellular Localization |
Membrane Peripheral membrane protein. Melanosome. |
|
| Protein Description | Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.. | |
| Protein Sequence | MALRAMRGIVNGAAPELPVPTGGPMAGAREQALAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDRGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTTAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFEKNFITQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Methylation | ----MALRAMRGIVN ----CHHHHHHHHHC | 19.46 | - | |
| 7 | Methylation | -MALRAMRGIVNGAA -CHHHHHHHHHCCCC | 30.60 | - | |
| 41 | Phosphorylation | AVSRNYLSQPRLTYK HHHCHHHCCCCCEEE | 27.98 | 25403869 | |
| 48 | Acetylation | SQPRLTYKTVSGVNG CCCCCEEEEECCCCC | 36.90 | 22902405 | |
| 64 | Acetylation | LVILDHVKFPRYAEI EEEEECCCCCCCEEE | 46.35 | 22902405 | |
| 81 | Acetylation | LTLPDGTKRSGQVLE EECCCCCCCCCCEEE | 50.53 | 22902405 | |
| 108 | Ubiquitination | GTSGIDAKKTSCEFT CCCCCCCCCCEEEEC | 53.49 | - | |
| 108 | Acetylation | GTSGIDAKKTSCEFT CCCCCCCCCCEEEEC | 53.49 | 22902405 | |
| 137 | Ubiquitination | RVFNGSGKPIDRGPV HHCCCCCCCCCCCCE | 40.26 | - | |
| 162 | S-nitrosylation | GQPINPQCRIYPEEM CCCCCCCCCCCHHHH | 2.77 | 22178444 | |
| 162 | S-nitrosocysteine | GQPINPQCRIYPEEM CCCCCCCCCCCHHHH | 2.77 | - | |
| 460 | Acetylation | EFLQKFEKNFITQGP HHHHHHHHHCCCCCC | 61.36 | 22902405 | |
| 460 | Ubiquitination | EFLQKFEKNFITQGP HHHHHHHHHCCCCCC | 61.36 | - | |
| 468 | Phosphorylation | NFITQGPYENRTVYE HCCCCCCCCCCCHHH | 32.43 | - | |
| 474 | Phosphorylation | PYENRTVYETLDIGW CCCCCCHHHHHHHHH | 11.55 | - | |
| 489 | Acetylation | QLLRIFPKEMLKRIP HHHHHCCHHHHHCCC | 45.03 | - | |
| 493 | Acetylation | IFPKEMLKRIPQSTL HCCHHHHHCCCHHHH | 47.15 | - | |
| 498 | Phosphorylation | MLKRIPQSTLSEFYP HHHCCCHHHHHHHCC | 26.43 | 25403869 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VATB2_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VATB2_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VATB2_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of VATB2_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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