VAMP2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VAMP2_RAT
• UniProt AC: P63045
• Protein Name: Vesicle-associated membrane protein 2
• Gene Name: Vamp2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 116
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Cell membrane . Neuronal synaptic vesicles. Colocalizes with PRKCZ and WDFY2 in intracellular vesicles.
• Protein Description: Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. [PubMed: 19690160]
• Protein Sequence: MSATAATVPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSATAATVP ------CCCCCCCCC	34.03	-
52	Acetylation	IMRVNVDKVLERDQK HHHCCHHHHHHHHHH	44.42	7769519
52	Ubiquitination	IMRVNVDKVLERDQK HHHCCHHHHHHHHHH	44.42	-
59	Acetylation	KVLERDQKLSELDDR HHHHHHHHHHHHHHH	59.26	7769531
59	Ubiquitination	KVLERDQKLSELDDR HHHHHHHHHHHHHHH	59.26	-
61	Phosphorylation	LERDQKLSELDDRAD HHHHHHHHHHHHHHH	43.05	25403869
75	Phosphorylation	DALQAGASQFETSAA HHHHHHHHHHHHHHH	34.19	30240740
79	Phosphorylation	AGASQFETSAAKLKR HHHHHHHHHHHHHHH	25.59	27097102
80	Phosphorylation	GASQFETSAAKLKRK HHHHHHHHHHHHHHH	21.02	27097102
85	Ubiquitination	ETSAAKLKRKYWWKN HHHHHHHHHHHHHHH	46.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VAMP2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VAMP2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VAMP2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNP25_MOUSE	Snap25	physical	10644763

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.