V1AR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: V1AR_HUMAN
• UniProt AC: P37288
• Protein Name: Vasopressin V1a receptor
• Gene Name: AVPR1A
• Organism: Homo sapiens (Human).
• Sequence Length: 418
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment..
• Protein Sequence: MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	N-linked_Glycosylation	PLATGAGNTSREAEA CCCCCCCCCHHHHHH	34.05	UniProtKB CARBOHYD
150	Phosphorylation	VVMTADRYIAVCHPL HHHCCCHHHHHCCCH	8.19	-
196	N-linked_Glycosylation	FSMIEVNNVTKARDC EEEEEECCEEEHHHH	48.27	UniProtKB CARBOHYD
278	Phosphorylation	LLAPCVSSVKSISRA CHHHHHHCCHHHHHH	17.11	27535140
281	Phosphorylation	PCVSSVKSISRAKIR HHHHCCHHHHHHHCC	24.52	-
283	Phosphorylation	VSSVKSISRAKIRTV HHCCHHHHHHHCCCC	33.02	-
348	Phosphorylation	SCCNPWIYMFFSGHL HCCCHHHHHHHCHHH	5.52	12436935
365	S-palmitoylation	DCVQSFPCCQNMKEK HHHHHCHHHHHHHHH	3.34	-
366	S-palmitoylation	CVQSFPCCQNMKEKF HHHHCHHHHHHHHHH	3.14	-
378	Phosphorylation	EKFNKEDTDSMSRRQ HHHCHHHCCHHHHHH	30.94	28060719
380	Phosphorylation	FNKEDTDSMSRRQTF HCHHHCCHHHHHHHH	22.28	28857561
382	Phosphorylation	KEDTDSMSRRQTFYS HHHCCHHHHHHHHHC	28.41	28060719
386	Phosphorylation	DSMSRRQTFYSNNRS CHHHHHHHHHCCCCC	23.80	28060719
404	Phosphorylation	STGMWKDSPKSSKSI CCCCCCCCCCCCCCC	30.42	28857561
407	Phosphorylation	MWKDSPKSSKSIKFI CCCCCCCCCCCCEEE	46.51	21712546
408	Phosphorylation	WKDSPKSSKSIKFIP CCCCCCCCCCCEEEE	36.23	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of V1AR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of V1AR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of V1AR_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of V1AR_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• D00101: Vasopressin (JP16/USP); Pitressin (TN)
• D00291: Desmopressin (INN)
• D00366: Lypressin (USP/INN); Diapid (TN)
• D01236: Conivaptan hydrochloride (JAN/USAN); Vaprisol (TN)
• D02235: Desmopressin acetate hydrate (JAN); Desmopressin acetate (USAN); Desmopressin acetate trihydrate; DD
• D02983: Argipressin tannate (USAN); Pitressin tannate (TN)
• D04137: Felypressin (USAN/INN); PLV-2 (TN)
• D06672: Terlipressin (USAN/INN); Lucassin (TN)
• D07227: Ornipressin (INN); POR 8 Sandoz (TN)
• D07748: Conivaptan (INN)
• D08571: Terlipressin acetate (JAN); Heamopressin (TN)
• D09820: Vasopressin tannate (JAN)
• DrugBank
• There are no disease associations of PTM sites.