UVH3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UVH3_ARATH
• UniProt AC: Q9ATY5
• Protein Name: DNA repair protein UVH3
• Gene Name: UVH3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1479
• Subcellular Localization: Nucleus .
• Protein Description: Putative single-stranded DNA endonuclease involved in nucleotide excision repair (NER) of UV- and oxidative damaged DNA. May make the 3'-incision step in NER. Seems to play a role in senescence program..
• Protein Sequence: MGVQGLWELLAPVGRRVSVETLANKRLAIDASIWMVQFIKAMRDEKGDMVQNAHLIGFFRRICKLLFLRTKPIFVFDGATPALKRRTVIARRRQRENAQTKIRKTAEKLLLNRLKDIRLKEQAKDIKNQRLKQDDSDRVKKRVSSDSVEDNLRVPVEEDDVGASFFQEEKLDEVSQASLVGETGVDDVVKESVKDDPKGKGVLLDGDDLDNLVQDSSVQGKDYQEKLDEMLAASLAAEEERNFTSKASTSAAAIPSEEDEEEDSDGDEEILLPVMDGNIDPAVLASLPPSMQLDLLAQMREKLMAENRQKYQKVKKAPEKFSELQIEAYLKTVAFRREINEVQRSAGGRAVGGVQTSRIASEANREFIFSSSFAGDKEVLASAREGRNDENQKKTSQQSLPVSVKNASPLKKSDATIELDRDEPKNPDENIEVYIDERGRFRIRNRHMGIQMTRDIQRNLHLMKEKERTASGSMAKNDETFSAWENFPTEDQFLEKSPVEKDVVDLEIQNDDSMLHPPSSIEISFDHDGGGKDLNDEDDMFLQLAAGGPVTISSTENDPKEDTSPWASDSDWEEVPVEQNTSVSKLEANLSNQHIPKDISIAEGVAWEEYSCKNANNSVENDTVTKITKGYLEEEADLQEAIKKSLLELHDKESGDVLEENQSVRVNLVVDKPSEDSLCSRETVGEAEEERFLDEITILKTSGAISEQSNTSVAGNADGQKGITKQFGTHPSSGSNNVSHAVSNKLSKVKSVISPEKALNVASQNRMLSTMAKQHNEEGSESFGGESVKVSAMPIADEEITGFLDEKDNADGESSIMMDDKRDYSRRKIQSLVTESRDPSRNVVRSRIGILHDTDSQNERREENNSNEHTFNIDSSTDFEEKGVPVEFSEANIEEEIRVLDQEFVSLGDEQRKLERNAESVSSEMFAECQELLQIFGIPYIIAPMEAEAQCAFMEQSNLVDGIVTDDSDVFLFGARSVYKNIFDDRKYVETYFMKDIEKELGLSRDKIIRMAMLLGSDYTEGISGIGIVNAIEVVTAFPEEDGLQKFREWVESPDPTILGKTDAKTGSKVKKRGSASVDNKGIISGASTDDTEEIKQIFMDQHRKVSKNWHIPLTFPSEAVISAYLNPQVDLSTEKFSWGKPDLSVLRKLCWEKFNWNGKKTDELLLPVLKEYEKRETQLRIEAFYSFNERFAKIRSKRINKAVKGIGGGLSSDVADHTLQEGPRKRNKKKVAPHETEDNNTSDKDSPIANEKVKNKRKRLEKPSSSRGRGRAQKRGRGRGRVQKDLLELSDGSSDDDDDDDKVVELEAKPANLQKSTRSRNPVMYSAKEDDELDESRSNEGSPSENFEEVDEGRIGNDDSVDASINDCPSEDYIQTGGGFCADEADEIGDAHLEDKATDDYRVIGGGFCVDEDETAEENTMDDDAEILKMESEEQRKKGKRRNEEDASLDENVDIHFGNSSAGGLSAMPFLKRKKRKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
480	Phosphorylation	SMAKNDETFSAWENF CCCCCCCCCCCHHCC	26.25	23776212
482	Phosphorylation	AKNDETFSAWENFPT CCCCCCCCCHHCCCC	39.63	23776212
489	Phosphorylation	SAWENFPTEDQFLEK CCHHCCCCHHHHHHC	48.32	23776212
497	Phosphorylation	EDQFLEKSPVEKDVV HHHHHHCCCCCCCCE	25.46	23776212
697	Phosphorylation	ERFLDEITILKTSGA HHHHHEEEEEEECCC	20.43	22074104
751	Phosphorylation	NKLSKVKSVISPEKA HHHHHCCCCCCHHHH	27.89	25561503
854	Phosphorylation	RIGILHDTDSQNERR HEEEECCCCCCCHHH	27.14	25561503
856	Phosphorylation	GILHDTDSQNERREE EEECCCCCCCHHHHH	36.68	29654922
1187	Phosphorylation	LRIEAFYSFNERFAK HHHHHHHHHHHHHHH	18.36	30291188
1237	Phosphorylation	KKVAPHETEDNNTSD CCCCCCCCCCCCCCC	45.67	23776212
1242	Phosphorylation	HETEDNNTSDKDSPI CCCCCCCCCCCCCCC	44.55	23776212
1243	Phosphorylation	ETEDNNTSDKDSPIA CCCCCCCCCCCCCCC	44.80	23776212
1247	Phosphorylation	NNTSDKDSPIANEKV CCCCCCCCCCCCHHH	24.77	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UVH3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UVH3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UVH3_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of UVH3_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.