UTY_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UTY_HUMAN
• UniProt AC: O14607
• Protein Name: Histone demethylase UTY
• Gene Name: UTY
• Organism: Homo sapiens (Human).
• Sequence Length: 1347
• Subcellular Localization: Nucleus .
• Protein Description: Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low lysine demethylase activity..
• Protein Sequence: MKSCAVSLTTAAVAFGDEAKKMAEGKASRESEEESVSLTVEEREALGGMDSRLFGFVRLHEDGARTKTLLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYSKALSAYQRYYSLQADYWKNAAFLYGLGLVYFYYNAFHWAIKAFQDVLYVDPSFCRAKEIHLRLGLMFKVNTDYKSSLKHFQLALIDCNPCTLSNAEIQFHIAHLYETQRKYHSAKEAYEQLLQTENLPAQVKATVLQQLGWMHHNMDLVGDKATKESYAIQYLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLGTLYESCNQPQDAIKCYLNAARSKRCSNTSTLAARIKFLQNGSDNWNGGQSLSHHPVQQVYSLCLTPQKLQHLEQLRANRDNLNPAQKHQLEQLESQFVLMQQMRHKEVAQVRTTGIHNGAITDSSLPTNSVSNRQPHGALTRVSSVSQPGVRPACVEKLLSSGAFSAGCIPCGTSKILGSTDTILLGSNCIAGSESNGNVPYLQQNTHTLPHNHTDLNSSTEEPWRKQLSNSAQGLHKSQSSCLSGPNEEQPLFSTGSAQYHQATSTGIKKANEHLTLPSNSVPQGDADSHLSCHTATSGGQQGIMFTKESKPSKNRSLVPETSRHTGDTSNGCADVKGLSNHVHQLIADAVSSPNHGDSPNLLIADNPQLSALLIGKANGNVGTGTCDKVNNIHPAVHTKTDHSVASSPSSAISTATPSPKSTEQRSINSVTSLNSPHSGLHTVNGEGLGKSQSSTKVDLPLASHRSTSQILPSMSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGRRRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQTLREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLSSSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MKSCAVSLTTAAVA -CCCCCHHHHHHHHH	11.06	28851738
9	Phosphorylation	KSCAVSLTTAAVAFG CCCCHHHHHHHHHHC	13.59	28851738
10	Phosphorylation	SCAVSLTTAAVAFGD CCCHHHHHHHHHHCH	20.22	28851738
20	Acetylation	VAFGDEAKKMAEGKA HHHCHHHHHHHCCCC	40.82	25953088
26	Acetylation	AKKMAEGKASRESEE HHHHHCCCCCCCCHH	34.39	25953088
28	Phosphorylation	KMAEGKASRESEEES HHHCCCCCCCCHHHC	39.81	30576142
37	Phosphorylation	ESEEESVSLTVEERE CCHHHCEEEEHHHHH	27.83	30576142
51	Phosphorylation	EALGGMDSRLFGFVR HHCCCCCHHHHEEEE	23.22	30576142
77	Phosphorylation	LGKAVRCYESLILKA HHHHHHHHHHHHHHC	9.66	30619164
79	Phosphorylation	KAVRCYESLILKAEG HHHHHHHHHHHHCCC	8.34	30619164
178	Phosphorylation	GLMFKVNTDYKSSLK CEEEEECCCCHHHHC	43.63	23898821
180	Phosphorylation	MFKVNTDYKSSLKHF EEEECCCCHHHHCCE	15.67	23898821
182	Phosphorylation	KVNTDYKSSLKHFQL EECCCCHHHHCCEEE	34.37	23898821
183	Phosphorylation	VNTDYKSSLKHFQLA ECCCCHHHHCCEEEE	36.97	23898821
222	Ubiquitination	QRKYHSAKEAYEQLL HHHHHCHHHHHHHHH	45.98	-
386	Phosphorylation	KRCSNTSTLAARIKF CCCCCHHHHHHHHHH	20.55	-
392	Ubiquitination	STLAARIKFLQNGSD HHHHHHHHHHHCCCC	34.17	-
421	Phosphorylation	QVYSLCLTPQKLQHL HHHHHHCCHHHHHHH	23.76	26074081
462	Ubiquitination	LMQQMRHKEVAQVRT HHHHHCCHHHCCHHC	43.44	-
468	Methylation	HKEVAQVRTTGIHNG CHHHCCHHCCCCCCC	17.94	-
498	Methylation	QPHGALTRVSSVSQP CCCCCEEECCCCCCC	27.46	-
500	Phosphorylation	HGALTRVSSVSQPGV CCCEEECCCCCCCCC	23.02	23312004
501	Phosphorylation	GALTRVSSVSQPGVR CCEEECCCCCCCCCC	23.96	23401153
503	Phosphorylation	LTRVSSVSQPGVRPA EEECCCCCCCCCCHH	32.38	23312004
583	Ubiquitination	STEEPWRKQLSNSAQ CCCHHHHHHHHHHCC	52.28	-
586	Phosphorylation	EPWRKQLSNSAQGLH HHHHHHHHHHCCCHH	26.67	23403867
588	Phosphorylation	WRKQLSNSAQGLHKS HHHHHHHHCCCHHCC	20.70	23403867
674	Phosphorylation	SKPSKNRSLVPETSR CCCCCCCCCCCCCHH	43.01	-
679	Phosphorylation	NRSLVPETSRHTGDT CCCCCCCCHHCCCCC	25.62	-
680	Phosphorylation	RSLVPETSRHTGDTS CCCCCCCHHCCCCCC	22.02	-
683	Phosphorylation	VPETSRHTGDTSNGC CCCCHHCCCCCCCCC	35.33	-
716	Phosphorylation	SSPNHGDSPNLLIAD HCCCCCCCCCEEECC	21.93	24247654
746	Acetylation	VGTGTCDKVNNIHPA CCCCCCCCCCCEECC	49.35	23749302
758	Phosphorylation	HPAVHTKTDHSVASS ECCEECCCCCCCCCC	39.85	28450419
761	Phosphorylation	VHTKTDHSVASSPSS EECCCCCCCCCCCCC	23.37	28450419
764	Phosphorylation	KTDHSVASSPSSAIS CCCCCCCCCCCCCCC	40.40	28450419
765	Phosphorylation	TDHSVASSPSSAIST CCCCCCCCCCCCCCC	21.04	28450419
767	Phosphorylation	HSVASSPSSAISTAT CCCCCCCCCCCCCCC	34.06	28450419
768	Phosphorylation	SVASSPSSAISTATP CCCCCCCCCCCCCCC	32.76	28450419
771	Phosphorylation	SSPSSAISTATPSPK CCCCCCCCCCCCCCC	16.23	28450419
772	Phosphorylation	SPSSAISTATPSPKS CCCCCCCCCCCCCCC	28.56	28450419
774	Phosphorylation	SSAISTATPSPKSTE CCCCCCCCCCCCCCC	25.12	28450419
776	Phosphorylation	AISTATPSPKSTEQR CCCCCCCCCCCCCCC	40.37	28450419
784	Phosphorylation	PKSTEQRSINSVTSL CCCCCCCCCCCCCCC	26.30	23312004
787	Phosphorylation	TEQRSINSVTSLNSP CCCCCCCCCCCCCCC	25.71	23312004
789	Phosphorylation	QRSINSVTSLNSPHS CCCCCCCCCCCCCCC	27.58	28122231
790	Phosphorylation	RSINSVTSLNSPHSG CCCCCCCCCCCCCCC	24.33	22617229
793	Phosphorylation	NSVTSLNSPHSGLHT CCCCCCCCCCCCCCC	29.32	28450419
796	Phosphorylation	TSLNSPHSGLHTVNG CCCCCCCCCCCCCCC	46.57	28122231
800	Phosphorylation	SPHSGLHTVNGEGLG CCCCCCCCCCCCCCC	22.25	22617229
808	Acetylation	VNGEGLGKSQSSTKV CCCCCCCCCCCCCCC	50.82	25953088
887	Phosphorylation	KDKLNPPTPSIYLEN CCCCCCCCCCEECCC	30.81	9381176
889	Phosphorylation	KLNPPTPSIYLENKR CCCCCCCCEECCCCC	26.75	22210691
911	Ubiquitination	HQFCTNPKNPVTVIR HHHCCCCCCCHHHHH	75.78	-
965	Ubiquitination	NWDPTGTKKIWRCES CCCCCCCCEEEEECC	43.54	-
1000	Ubiquitination	SLREENEKRTQHKDH HHHHHHHHHHCCCCC	72.78	-
1028	Phosphorylation	RRKGPFKTIKFGTNI CCCCCCCEEEECCCC	29.76	21964256
1033	Phosphorylation	FKTIKFGTNIDLSDN CCEEEECCCCCCCCC	31.94	18491316
1038	Phosphorylation	FGTNIDLSDNKKWKL ECCCCCCCCCCCEEE	35.08	18491316
1041	Ubiquitination	NIDLSDNKKWKLQLH CCCCCCCCCEEEEHH	66.07	-
1044	Ubiquitination	LSDNKKWKLQLHELT CCCCCCEEEEHHHHH	34.92	-
1052	Ubiquitination	LQLHELTKLPAFARV EEHHHHHCCHHHHHH	66.16	-
1061	Phosphorylation	PAFARVVSAGNLLTH HHHHHHHHHHHHHHH	27.83	22210691
1078	Phosphorylation	HTILGMNTVQLYMKV CHHCCCCEEEEEEEC	10.75	-
1101	Phosphorylation	QENNNFCSVNINIGP CCCCCEEEEEEEECC	17.67	-
1207	Ubiquitination	VERYEWNKLKSVKSP HHHHHHHHCCCCCCC	59.36	-
1213	Phosphorylation	NKLKSVKSPVPMVHL HHCCCCCCCCCEEEE	29.04	22210691
1231	Phosphorylation	MARNIKVSDPKLFEM HHCCCCCCCHHHHHH	43.10	22210691
1234	Ubiquitination	NIKVSDPKLFEMIKY CCCCCCHHHHHHHHH	71.45	-
1248	Ubiquitination	YCLLKILKQYQTLRE HHHHHHHHHHHHHHH	50.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UTY_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UTY_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UTY_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TLE1_HUMAN	TLE1	physical	9854018
TLE2_HUMAN	TLE2	physical	9854018

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.